RG7834 R-isomer

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555327

CAS#: 2072057-18-0 (R-isomer)

Description: RG7834 R-isomer, also known as RO0321, is an enantiomer of RG7834 and a negative control for RG7834. RG7834 R-isomer has R-configuration with CAS#2072057-18-0. RG7834 is a novel oral HBV viral gene expression inhibitor that blocks viral antigen and virion production. RG7834 is highly selective for HBV, and has a unique antiviral profile that is clearly differentiated from nucleos(t)ide analogues.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 330 Same day
50mg USD 550 Same day
100mg USD 950 Same day
200mg USD 1850 Same day
Inquire bulk and customized quantity

Pricing updated 2021-01-24. Prices are subject to change without notice.

RG7834 R-isomer, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555327
Name: RG7834 R-isomer
CAS#: 2072057-18-0 (R-isomer)
Chemical Formula: C22H27NO6
Exact Mass: 401.1838
Molecular Weight: 401.459
Elemental Analysis: C, 65.82; H, 6.78; N, 3.49; O, 23.91

Related CAS #: 199482-36-3 (S-isomer hydrate)   2072057-17-9 (S-isomer)   2072057-18-0 (R-isomer)   1802407-46-0 (racemic)  

Synonym: RG7834 R-isomer; RG 7834 R-isomer; RG-7834 R-isomer; RO7020322 R-isomer; RO 7020322 R-isomer; RO-7020322 R-isomer; RO0321; RO-0321; RO 0321;

IUPAC/Chemical Name: (6R)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid


InChi Code: InChI=1S/C22H27NO6/c1-13(2)17-8-14-9-21(29-7-5-6-27-3)20(28-4)10-15(14)18-11-19(24)16(22(25)26)12-23(17)18/h9-13,17H,5-8H2,1-4H3,(H,25,26)/t17-/m1/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Mueller H, Lopez A, Tropberger P, Wildum S, Schmaler J, Pedersen L, Han X,
Wang Y, Ottosen S, Yang S, Young JAT, Javanbakht H. PAPD5/7 Are Host Factors That
Are Required for Hepatitis B Virus RNA Stabilization. Hepatology. 2019
Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1. PubMed PMID:

2: Han X, Zhou C, Jiang M, Wang Y, Wang J, Cheng Z, Wang M, Liu Y, Liang C, Wang
J, Wang Z, Weikert R, Lv W, Xie J, Yu X, Zhou X, Luangsay S, Shen HC, Mayweg AV,
Javanbakht H, Yang S. Discovery of RG7834: The First-in-Class Selective and
Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel
Mechanism of Action. J Med Chem. 2018 Dec 13;61(23):10619-10634. doi:
10.1021/acs.jmedchem.8b01245. Epub 2018 Oct 17. PubMed PMID: 30286292.

3: Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani
G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F,
Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT,
Javanbakht H. A novel orally available small molecule that inhibits hepatitis B
virus expression. J Hepatol. 2018 Mar;68(3):412-420. doi:
10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25. PubMed PMID: 29079285.