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MedKoo CAT#: 581386

CAS#: 121749-39-1

Description: N(1),N(11)-Diethylnorspermine tetrahydrochloride is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 260 2 Weeks
100mg USD 750 2 Weeks
500mg USD 2000 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-04. Prices are subject to change without notice.

N(1),N(11)-Diethylnorspermine , purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581386
Name: N(1),N(11)-Diethylnorspermine
CAS#: 121749-39-1
Chemical Formula: C13H32N4
Exact Mass: 244.2627
Molecular Weight: 244.427
Elemental Analysis: C, 63.88; H, 13.20; N, 22.92

Synonym: N(1),N(11)-Diethylnorspermine; De 333; DE-333; BE 3-3-3; DENSPM;

IUPAC/Chemical Name: 1,11-Bis(ethylamino)-4,8-diazaundecan


InChi Code: InChI=1S/C13H32N4/c1-3-14-8-5-10-16-12-7-13-17-11-6-9-15-4-2/h14-17H,3-13H2,1-2H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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enhances DENSpm-induced apoptosis in human colon cancer cells in a p53
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2: Xie Y, Murray-Stewart T, Wang Y, Yu F, Li J, Marton LJ, Casero RA Jr, Oupický
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3: Akyol Z, Çoker-Gürkan A, Arisan ED, Obakan-Yerlikaya P, Palavan-Ünsal N.
DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7
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4: Mounce BC, Cesaro T, Moratorio G, Hooikaas PJ, Yakovleva A, Werneke SW, Smith
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Frenkiel MP, Sakuntabhai A, Delpeyroux F, Pardigon N, Flamand M, Barba-Spaeth G,
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Is a Broad-Spectrum Strategy against RNA Viruses. J Virol. 2016 Oct
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5: Chanphai P, Tajmir-Riahi HA. Thermodynamic analysis of biogenic and synthetic
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PMID: 26722998.

6: Çoker-Gürkan A, Arisan ED, Obakan P, Palavan-Unsal N. Lack of functional p53
renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon
cancer cells. Amino Acids. 2015 Jan;47(1):87-100. doi: 10.1007/s00726-014-1851-7.
Epub 2014 Oct 14. PubMed PMID: 25311224.

7: Ray RM, Bhattacharya S, Bavaria MN, Viar MJ, Johnson LR. Spermidine, a sensor
for antizyme 1 expression regulates intracellular polyamine homeostasis. Amino
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8: Andersen SM, Taylor R, Holen E, Aksnes A, Espe M. Arginine supplementation and
exposure time affects polyamine and glucose metabolism in primary liver cells
isolated from Atlantic salmon. Amino Acids. 2014 May;46(5):1225-33. doi:
10.1007/s00726-014-1684-4. Epub 2014 Feb 6. PubMed PMID: 24500114.

9: Goyal L, Supko JG, Berlin J, Blaszkowsky LS, Carpenter A, Heuman DM,
Hilderbrand SL, Stuart KE, Cotler S, Senzer NN, Chan E, Berg CL, Clark JW, Hezel
AF, Ryan DP, Zhu AX. Phase 1 study of N(1),N(11) diethylnorspermine (DENSPM) in
patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 2013
Dec;72(6):1305-14. PubMed PMID: 24121453.

10: Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C, Nicolini B, Falconi
M, Farruggia G, Cappadone C, Stefanelli C. Synthetic polyamines activating
autophagy: effects on cancer cell death. Eur J Med Chem. 2013 Sep;67:359-66. doi:
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11: Perez-Leal O, Abou-Gharbia M, Gordon J, Childers WE, Merali S. A novel assay
platform for the detection of translation modulators of spermidine/spermine
acetyltransferase. Curr Pharm Des. 2014;20(2):245-52. PubMed PMID: 23701549;
PubMed Central PMCID: PMC3871977.

12: Tian Y, Wang S, Wang B, Zhang J, Jiang R, Zhang W. Overexpression of SSAT by
DENSPM treatment induces cell detachment and apoptosis in glioblastoma. Oncol
Rep. 2012 Apr;27(4):1227-32. doi: 10.3892/or.2011.1592. Epub 2011 Dec 14. PubMed
PMID: 22179681; PubMed Central PMCID: PMC3583519.

13: Uimari A, Merentie M, Sironen R, Pirnes-Karhu S, Peräniemi S, Alhonen L.
Overexpression of spermidine/spermine N1-acetyltransferase or treatment with
N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in
mouse. Amino Acids. 2012 Feb;42(2-3):461-71. doi: 10.1007/s00726-011-1025-9. Epub
2011 Aug 4. PubMed PMID: 21814793.

14: Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA Jr.
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation
leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and
toxicity in NCI H157 lung cancer cells. Amino Acids. 2012 Feb;42(2-3):529-38.
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PubMed PMID: 21809081.

16: Hyvönen MT, Uimari A, Vepsäläinen J, Khomutov AR, Keinänen TA, Alhonen L.
Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.
Amino Acids. 2012 Feb;42(2-3):485-93. doi: 10.1007/s00726-011-1027-7. Epub 2011
Aug 2. PubMed PMID: 21809078.

17: Kreutzer JN, Olsen BB, Lech K, Issinger OG, Guerra B. Role of polyamines in
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PMID: 21750985.

18: Facchini A, Stanic I, Cetrullo S, Borzì RM, Filardo G, Flamigni F.
Sulforaphane protects human chondrocytes against cell death induced by various
stimuli. J Cell Physiol. 2011 Jul;226(7):1771-9. doi: 10.1002/jcp.22506. PubMed
PMID: 21506109.

19: Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M,
Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA Jr, Mariottini
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analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer.
2010 Oct 14;10:555. doi: 10.1186/1471-2407-10-555. PubMed PMID: 20946629; PubMed
Central PMCID: PMC3027604.

20: Söderstjerna E, Holst CM, Alm K, Oredsson SM. Apoptosis induced by the
potential chemotherapeutic drug N1, N11-Diethylnorspermine in a neuroblastoma
cell line. Anticancer Drugs. 2010 Nov;21(10):917-26. doi:
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