Diethylnorspermine HCl
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MedKoo CAT#: 581386

CAS#: 156886-85-0 (4HCl)

Description: Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..


Chemical Structure

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Diethylnorspermine HCl
CAS# 156886-85-0 (4HCl)

Theoretical Analysis

MedKoo Cat#: 581386
Name: Diethylnorspermine HCl
CAS#: 156886-85-0 (4HCl)
Chemical Formula: C13H36Cl4N4
Exact Mass: 244.2627
Molecular Weight: 390.259
Elemental Analysis: C, 40.01; H, 9.30; Cl, 36.33; N, 14.36

Price and Availability

Size Price Availability Quantity
10.0mg USD 350.0 2 Weeks
50.0mg USD 1350.0 2 Weeks
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Related CAS #: 121749-39-1 (free base)   156886-85-0 (HCl)   1384898-58-1 (HBr)    

Synonym: BE-333 HCl; BE-333 tetrahydrochloride; N(1),N(11)-Diethylnorspermine; DE 333; DE-333; DE333; BE 3-3-3; BE 333; BE333; BE-333; BENSPM; DENSPM; Diethyl-norspermine; N1,N11-Bis(ethyl)norspermine; N1,N11-Diethylnorspermine;

IUPAC/Chemical Name: 1,11-Bis(ethylamino)-4,8-diazaundecan tetrahydrochloride

InChi Key: LAWBSOKBIROCQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H32N4.4ClH/c1-3-14-8-5-10-16-12-7-13-17-11-6-9-15-4-2;;;;/h14-17H,3-13H2,1-2H3;4*1H

SMILES Code: CCNCCCNCCCNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 390.259 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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enhances DENSpm-induced apoptosis in human colon cancer cells in a p53
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6: Çoker-Gürkan A, Arisan ED, Obakan P, Palavan-Unsal N. Lack of functional p53
renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon
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12: Tian Y, Wang S, Wang B, Zhang J, Jiang R, Zhang W. Overexpression of SSAT by
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13: Uimari A, Merentie M, Sironen R, Pirnes-Karhu S, Peräniemi S, Alhonen L.
Overexpression of spermidine/spermine N1-acetyltransferase or treatment with
N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in
mouse. Amino Acids. 2012 Feb;42(2-3):461-71. doi: 10.1007/s00726-011-1025-9. Epub
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14: Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA Jr.
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation
leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and
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Aug 2. PubMed PMID: 21809078.

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PMID: 21506109.

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Central PMCID: PMC3027604.

20: Söderstjerna E, Holst CM, Alm K, Oredsson SM. Apoptosis induced by the
potential chemotherapeutic drug N1, N11-Diethylnorspermine in a neuroblastoma
cell line. Anticancer Drugs. 2010 Nov;21(10):917-26. doi:
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