Netilmicin

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341396

CAS#: 56391-56-1

Description: Netilmicin is a member of the aminoglycoside family of antibiotics.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

Netilmicin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 341396
Name: Netilmicin
CAS#: 56391-56-1
Chemical Formula: C21H41N5O7
Exact Mass: 475.3006
Molecular Weight: 475.587
Elemental Analysis: C, 53.04; H, 8.69; N, 14.73; O, 23.55


Synonym: Netilmicin; BRN 5316582; BRN-5316582; BRN5316582.

IUPAC/Chemical Name: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl(1-4))-2-deoxy-N(sup 1)-ethyl-

InChi Key: CIDUJQMULVCIBT-MQDUPKMGSA-N

InChi Code: InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+/m1/s1

SMILES Code: CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@H]2OC[C@](O)([C@@H]([C@H]2O)NC)C)O)O[C@H]3OC(CN)=CC[C@H]3N)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Szymanek-Majchrzak K, Mlynarczyk A, Kawecki D, Pacholczyk M, Durlik M, Deborska-Materkowska D, Paczek L, Mlynarczyk G. Resistance to Aminoglycosides of Methicillin-Resistant Strains of Staphylococcus aureus, Originating in the Surgical and Transplantation Wards of the Warsaw Clinical Center-A Retrospective Analysis. Transplant Proc. 2018 Sep;50(7):2170-2175. doi: 10.1016/j.transproceed.2018.02.158. Epub 2018 Mar 15. PubMed PMID: 30177131.

2: Albu S, Voidazan S, Bilca D, Badiu M, Truţă A, Ciorea M, Ichim A, Luca D, Moldovan G. Bacteriuria and asymptomatic infection in chronic patients with indwelling urinary catheter: The incidence of ESBL bacteria. Medicine (Baltimore). 2018 Aug;97(33):e11796. doi: 10.1097/MD.0000000000011796. PubMed PMID: 30113467; PubMed Central PMCID: PMC6112905.

3: Kiran KC, Madhukara J, Abraham A, Muralidharan S. Cutaneous Bacteriological Profile in Patients with Pemphigus. Indian J Dermatol. 2018 Jul-Aug;63(4):301-304. doi: 10.4103/ijd.IJD_152_17. PubMed PMID: 30078873; PubMed Central PMCID: PMC6052748.

4: Chandrasekhar D, Dollychan A, Roy BM, Cholamughath S, Parambil JC. Prevalence and antibiotic utilization pattern of uropathogens causing community-acquired urinary tract infection in Kerala, India. J Basic Clin Physiol Pharmacol. 2018 Jul 31. pii: /j/jbcpp.ahead-of-print/jbcpp-2018-0015/jbcpp-2018-0015.xml. doi: 10.1515/jbcpp-2018-0015. [Epub ahead of print] PubMed PMID: 30063465.

5: Nasiri G, Peymani A, Farivar TN, Hosseini P. Molecular epidemiology of aminoglycoside resistance in clinical isolates of Klebsiella pneumoniae collected from Qazvin and Tehran provinces, Iran. Infect Genet Evol. 2018 Oct;64:219-224. doi: 10.1016/j.meegid.2018.06.030. Epub 2018 Jun 28. PubMed PMID: 29964191.

6: Sipahi OR, Mermer S, Demirdal T, Ulu AC, Fillatre P, Ozcem SB, Kaya Ş, Şener A, Bulut C, Tekin R, Kahraman H, Özgiray E, Yurtseven T, Sipahi H, Arda B, Pullukçu H, Taşbakan M, Yamazhan T, Aydemir S, Ulusoy S. Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis: Results of the Ege study. Clin Neurol Neurosurg. 2018 Sep;172:31-38. doi: 10.1016/j.clineuro.2018.06.008. Epub 2018 Jun 10. PubMed PMID: 29960893.

7: Khanra S, Kumar YP, Dash J, Banerjee R. In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin. BMC Res Notes. 2018 May 21;11(1):319. doi: 10.1186/s13104-018-3446-y. PubMed PMID: 29784022; PubMed Central PMCID: PMC5963029.

8: Fernández-Martínez M, Ruiz Del Castillo B, Lecea-Cuello MJ, Rodríguez-Baño J, Pascual Á, Martínez-Martínez L; Spanish Network for the Research in Infectious Diseases (REIPI) and the Spanish Group for Nosocomial Infections (GEIH). Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain. Microb Drug Resist. 2018 May;24(4):367-376. doi: 10.1089/mdr.2017.0102. Epub 2017 Oct 3. PubMed PMID: 29727265; PubMed Central PMCID: PMC5946734.

9: Seyedi-Marghaki F, Kalantar-Neyestanaki D, Saffari F, Hosseini-Nave H, Moradi M. Distribution of Aminoglycoside-Modifying Enzymes and Molecular Analysis of the Coagulase Gene in Clinical Isolates of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus. Microb Drug Resist. 2018 Apr 30. doi: 10.1089/mdr.2017.0121. [Epub ahead of print] PubMed PMID: 29708846.

10: Zhou JW, Chen TT, Tan XJ, Sheng JY, Jia AQ. Can the quorum sensing inhibitor resveratrol function as an aminoglycoside antibiotic accelerant against Pseudomonas aeruginosa? Int J Antimicrob Agents. 2018 Jul;52(1):35-41. doi: 10.1016/j.ijantimicag.2018.03.002. Epub 2018 Mar 9. PubMed PMID: 29530588.

11: Rizwan M, Akhtar M, Najmi AK, Singh K. Escherichia coli and Klebsiella pneumoniae Sensitivity/Resistance Pattern Towards Antimicrobial Agents in Primary and Simple Urinary Tract Infection Patients Visiting University Hospital of Jamia Hamdard New Delhi. Drug Res (Stuttg). 2018 Jul;68(7):415-420. doi: 10.1055/a-0576-0079. Epub 2018 Mar 12. PubMed PMID: 29529677.

12: Nordmann P, Mazé A, Culebras E, Dobias J, Jayol A, Poirel L. A culture medium for screening 16S rRNA methylase-producing pan-aminoglycoside resistant Gram-negative bacteria. Diagn Microbiol Infect Dis. 2018 Jun;91(2):118-122. doi: 10.1016/j.diagmicrobio.2018.01.026. Epub 2018 Feb 3. PubMed PMID: 29496380.

13: Islam MN, Ahmed D, Hossain MA, Ahsan CR, Yasmin M. Prevalence of Metallo-β-lactamase Producing Non-fermentative Pseudomonas Species from Clinical Isolates in Dhaka, Bangladesh. Mymensingh Med J. 2018 Jan;27(1):89-94. PubMed PMID: 29459597.

14: Zhou JW, Luo HZ, Jiang H, Jian TK, Chen ZQ, Jia AQ. Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa. J Agric Food Chem. 2018 Feb 21;66(7):1620-1628. doi: 10.1021/acs.jafc.7b05035. Epub 2018 Feb 8. PubMed PMID: 29353476.

15: Márquez MLF, Burgos MJG, Pulido RP, Gálvez A, López RL. Correlations among Resistances to Different Antimicrobial Compounds in Salmonella Strains from Hen Eggshells. J Food Prot. 2018 Feb;81(2):178-185. doi: 10.4315/0362-028X.JFP-17-200. PubMed PMID: 29315029.

16: Gagliano C, Papa V, Amato R, Malaguarnera G, Avitabile T. Measurement of the Retention Time of Different Ophthalmic Formulations with Ultrahigh-Resolution Optical Coherence Tomography. Curr Eye Res. 2018 Apr;43(4):499-502. doi: 10.1080/02713683.2017.1418893. Epub 2017 Dec 28. PubMed PMID: 29283672.

17: Ustaoglu M, Solmaz N, Onder F. Ocular surface chemical injury treated by regenerating agent (RGTA, Cacicol20). GMS Ophthalmol Cases. 2017 Oct 25;7:Doc28. doi: 10.3205/oc000079. eCollection 2017. PubMed PMID: 29082123; PubMed Central PMCID: PMC5655981.

18: Silva FA, Conde-Felipe M, Rosario I, Ferrer O, Real F, Déniz S, Acosta F, Padilla D, Acosta-Hernández B. Susceptibility of Malassezia pachydermatis to aminoglycosides. Mycoses. 2017 Dec;60(12):796-799. doi: 10.1111/myc.12665. Epub 2017 Sep 19. PubMed PMID: 28925032.

19: Oduor JMO, Onkoba N, Maloba F, Nyachieo A. Experimental phage therapy against haematogenous multi-drug resistant Staphylococcus aureus pneumonia in mice. Afr J Lab Med. 2016 Sep 30;5(1):435. doi: 10.4102/ajlm.v5i1.435. eCollection 2016. PubMed PMID: 28879116; PubMed Central PMCID: PMC5436407.

20: Yang B, Wang L, Luo C, Wang X, Sun C. Simultaneous Determination of 11 Aminoglycoside Residues in Honey, Milk, and Pork by Liquid Chromatography with Tandem Mass Spectrometry and Molecularly Imprinted Polymer Solid Phase Extraction. J AOAC Int. 2017 Nov 1;100(6):1869-1878. doi: 10.5740/jaoacint.16-0399. Epub 2017 Aug 8. PubMed PMID: 28786377. h