WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581367
Description: VUN 37586, also known as De(5-carboxamide)oxcarbazepine is a compound useful in organic synthesis. This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number or its molecule weight if its CAS number is not available (see MedKoo Chemical Nomenclature, https://www.medkoo.com/page/naming).
MedKoo Cat#: 581367
Name: VUN 37586
Chemical Formula: C14H11NO
Exact Mass: 209.0841
Molecular Weight: 209.248
Elemental Analysis: C, 80.36; H, 5.30; N, 6.69; O, 7.65
Synonym: De(5-carboxamide)oxcarbazepine; Oxcarbazepine impurity C; Oxcarbazepine related compound E; VUN 37586; VUN-37586; VUN37586
IUPAC/Chemical Name: 10H-Dibenz(b,f)azepin-10-one, 5,11-dihydro-
InChi Key: VSZGCLXGCOECAY-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11NO/c16-14-9-10-5-1-3-7-12(10)15-13-8-4-2-6-11(13)14/h1-8,15H,9H2
SMILES Code: O=C1CC2=CC=CC=C2NC3=CC=CC=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 209.248 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
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8: Araújo IM, Ambrósio AF, Leal EC, Verdasca MJ, Malva JO, Soares-da-Silva P, Carvalho AP, Carvalho CM. Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093. Epilepsia. 2004 Dec;45(12):1498-505. PubMed PMID: 15571507.
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11: Ambrósio AF, Soares-Da-Silva P, Carvalho CM, Carvalho AP. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem Res. 2002 Feb;27(1-2):121-30. Review. PubMed PMID: 11926264.
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13: Learmonth DA, Benes J, Parada A, Hainzl D, Beliaev A, Bonifácio MJ, Matias PM, Carrondo MA, Garrett J, Soares-da-Silva P. Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives. Eur J Med Chem. 2001 Mar;36(3):227-36. PubMed PMID: 11337101.
14: Ambrósio AF, Silva AP, Malva JO, Soares-da-Silva P, Carvalho AP, Carvalho CM. Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels. Biochem Pharmacol. 2001 May 15;61(10):1271-5. PubMed PMID: 11322931.
15: Kiguchi S, Ichikawa K, Kojima M. Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats. Clin Exp Pharmacol Physiol. 2001 Mar;28(3):169-75. PubMed PMID: 11207671.
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