MBX-1066

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564008

CAS#: 868971-24-8 (free base)

Description: MBX-1066 is a potent antibacterial agent against a wide range of Gram-positive and Gram-negative bacteria.

Chemical Structure

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MBX-1066
CAS# 868971-24-8 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 564008
Name: MBX-1066
CAS#: 868971-24-8 (free base)
Chemical Formula: C28H24N6
Exact Mass: 444.21
Molecular Weight: 444.540
Elemental Analysis: C, 75.65; H, 5.44; N, 18.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1429919-10-7 (TFA)   868971-24-8 (free base),  

Synonym: MBX-1066; MBX1066; MBX 1066

IUPAC/Chemical Name: 6-(4,5-Dihydro-1H-imidazol-2-yl)-2-[4-[6-(4,5-dihydro-1H-imidazol-2-yl)-1H-indol-2-yl]phenyl]-1H-indole

InChi Key: BYXATBRFGOLYAB-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H24N6/c1-2-18(24-14-20-6-8-22(16-26(20)34-24)28-31-11-12-32-28)4-3-17(1)23-13-19-5-7-21(15-25(19)33-23)27-29-9-10-30-27/h1-8,13-16,33-34H,9-12H2,(H,29,30)(H,31,32)

SMILES Code: C(N1)(C2=CC=C(C(N3)=CC4=C3C=C(C5=NCCN5)C=C4)C=C2)=CC6=C1C=C(C7=NCCN7)C=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Opperman TJ, Kwasny SM, Li JB, Lewis MA, Aiello D, Williams JD, Peet NP, Moir DT, Bowlin TL, Long EC. DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7067-7076. Print 2016 Dec. PubMed PMID: 27620482; PubMed Central PMCID: PMC5118985.

2: Williams JD, Nguyen ST, Gu S, Ding X, Butler MM, Tashjian TF, Opperman TJ, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL. Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090. Bioorg Med Chem. 2013 Dec 15;21(24):7790-806. doi: 10.1016/j.bmc.2013.10.014. Epub 2013 Oct 25. PubMed PMID: 24239389; PubMed Central PMCID: PMC3906850.