WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564007
CAS#: 1632498-56-6
Description: YH18968 is a GPR119 agonist, improving glucose tolerance and augmenting the glucose lowering effect. YH18968 augments the plasma level of active GLP-1 in normal mice in combination treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor.
MedKoo Cat#: 564007
Name: YH18968
CAS#: 1632498-56-6
Chemical Formula: C27H28FN9O3
Exact Mass: 545.2299
Molecular Weight: 545.58
Elemental Analysis: C, 59.44; H, 5.17; F, 3.48; N, 23.11; O, 8.80
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Synonym: YH18968; YH-18968; YH 18968
IUPAC/Chemical Name: (S)-5-(3-Fluoro-4-(5-oxo-1-(tetrahydrofuran-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)-2-(4-(5-isopropyl1,2,4-oxadiazol-3-yl)piperazin-1-yl)nicotinonitrile
InChi Key: READJNFYOAOOFN-NRFANRHFSA-N
InChi Code: InChI=1S/C27H28FN9O3/c1-17(2)25-32-26(33-40-25)35-8-6-34(7-9-35)24-19(13-29)11-20(14-30-24)18-3-4-23(22(28)12-18)36-16-31-37(27(36)38)21-5-10-39-15-21/h3-4,11-12,14,16-17,21H,5-10,15H2,1-2H3/t21-/m0/s1
SMILES Code: N#CC1=C(N2CCN(C3=NOC(C(C)C)=N3)CC2)N=CC(C4=CC=C(N5C=NN([C@@H]6COCC6)C5=O)C(F)=C4)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 545.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Han T, Lee BM, Park YH, Lee DH, Choi HH, Lee T, Kim H. YH18968, a Novel 1,2,4-Triazolone G-Protein Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes Mellitus. Biomol Ther (Seoul). 2018 Mar 1;26(2):201-209. doi: 10.4062/biomolther.2018.011. PubMed PMID: 29495245; PubMed Central PMCID: PMC5839499.
