DSP-6952

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563992

CAS#: 1184661-33-3

Description: DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction.

Chemical Structure

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DSP-6952
CAS# 1184661-33-3
Instruction

Theoretical Analysis

MedKoo Cat#: 563992
Name: DSP-6952
CAS#: 1184661-33-3
Chemical Formula: C21H36BrClN4O7
Exact Mass: 570.15
Molecular Weight: 571.890
Elemental Analysis: C, 44.10; H, 6.35; Br, 13.97; Cl, 6.20; N, 9.80; O, 19.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DSP-6952; DSP6952; DSP 6952

IUPAC/Chemical Name: (S)-4-Amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide Hydrobromide dihydrate

InChi Key: PNMMVYQNYDDJNF-CFZZCFLMSA-N

InChi Code: InChI=1S/C21H31ClN4O5.BrH.2H2O/c1-30-19-9-18(23)17(22)8-16(19)21(29)24-10-15-12-25(6-7-31-15)11-14-2-4-26(5-3-14)20(28)13-27;;;/h8-9,14-15,27H,2-7,10-13,23H2,1H3,(H,24,29);1H;2*1H2/t15-;;;/m0.../s1

SMILES Code: O=C(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)C3=CC(Cl)=C(N)C=C3OC.[H]Br.[H]O[H].[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 571.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mine Y, Itakura T, Oku S, Asada R, Shimizu I. DSP-6952, a novel 5-HT(4) receptor partial agonist, inhibits visceral hypersensitivity and ameliorates gastrointestinal dysfunction in experimental animals. Eur J Pharmacol. 2018 May 5;826:123-132. doi: 10.1016/j.ejphar.2018.02.005. Epub 2018 Feb 9. PubMed PMID: 29428470.

2: Tsubouchi T, Kunimatsu T, Tsujimoto S, Kiyoshi A, Katsura Y, Oku S, Chihara K, Mine Y, Yamada T, Shimizu I, Bando K. The in vitro pharmacology and non-clinical cardiovascular safety studies of a novel 5-HT(4) receptor agonist, DSP-6952. Eur J Pharmacol. 2018 May 5;826:96-105. doi: 10.1016/j.ejphar.2018.02.037. Epub 2018 Mar 1. PubMed PMID: 29501863.