NPD8716 | CAS#956944-02-8 | HBV/HDV Inhibitor

NPD8716
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563972

CAS#: 956944-02-8

Description: NPD8716 is a hepatitis B/D virus entry inhibitor, targeting sodium taurocholate cotransporting polypeptide (NTCP).

Chemical Structure

NPD8716

CAS# 956944-02-8

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563972
Name: NPD8716
CAS#: 956944-02-8
Chemical Formula: C23H31NO6S
Exact Mass: 449.19
Molecular Weight: 449.562
Elemental Analysis: C, 61.45; H, 6.95; N, 3.12; O, 21.35; S, 7.13

Price and Availability

Size	Price	Availability
5mg	USD 435	2 Weeks
10mg	USD 715	2 Weeks
25mg	USD 1350	2 Weeks
50mg	USD 2250	2 Weeks
100mg	USD 3650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NPD8716; NPD-8716; NPD 8716

IUPAC/Chemical Name: (2-((3-Hexyl-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)methionine

InChi Key: AQIJSZWSLQTHAP-IBGZPJMESA-N

InChi Code: InChI=1S/C23H31NO6S/c1-4-5-6-7-8-18-15(2)17-10-9-16(13-20(17)30-23(18)28)29-14-21(25)24-19(22(26)27)11-12-31-3/h9-10,13,19H,4-8,11-12,14H2,1-3H3,(H,24,25)(H,26,27)/t19-/m0/s1

SMILES Code: CSCC[C@@H](C(O)=O)NC(COC1=CC(O2)=C(C=C1)C(C)=C(CCCCCC)C2=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	NPD8716 is a hepatitis B/D virus entry inhibitor.
In vitro activity:	One of such compound, NPD8716, a coumarin derivative, interacted with NTCP and inhibited HBV infection without causing cytotoxicity. Consistent with its NTCP interaction capacity, this compound was shown to block viral attachment to host hepatocytes. NPD8716 also prevented the infection with hepatitis D virus, but not hepatitis C virus, in agreement with NPD8716 specifically inhibiting NTCP-mediated infection. Reference: Sci Rep. 2018 Feb 9;8(1):2769. https://pubmed.ncbi.nlm.nih.gov/29426822/
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 449.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K. Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide. Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w. PMID: 29426822; PMCID: PMC5807303.
In vitro protocol:	Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K. Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide. Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w. PMID: 29426822; PMCID: PMC5807303.
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park SY, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K. Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide. Sci Rep. 2018 Feb 9;8(1):2769. doi: 10.1038/s41598-018-20987-w. PubMed PMID: 29426822; PubMed Central PMCID: PMC5807303.

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