WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581312
CAS#: 546-93-0
Description: Magnesium carbonate is a chemical used in the production of magnesium oxide by calcining. Amorphous magnesium carbonate nanoparticles with strong stabilizing capability for amorphous ibuprofen. improved apparent solubility and enhanced bioavailability of drugs.
MedKoo Cat#: 581312
Name: Magnesium carbonate
CAS#: 546-93-0
Chemical Formula: CMgO3
Exact Mass: 83.9698
Molecular Weight: 84.313
Elemental Analysis: C, 14.25; Mg, 28.83; O, 56.93
Synonym: Magnesium carbonate; Magnesite; Magmaster; Magfy;
IUPAC/Chemical Name: Carbonic acid, magnesium salt (1:1)
InChi Key: ZLNQQNXFFQJAID-UHFFFAOYSA-L
InChi Code: InChI=1S/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
SMILES Code: [O-]C([O-])=O.[Mg+2]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
| Biological target: | Magnesium carbonate is a chemical used in the production of magnesium oxide by calcining. |
| In vitro activity: | This study reports a method to synthesize dolomite [CaMg(CO3)2] from amorphous calcium magnesium carbonate (ACMC) via solid-state transformation. When ACMC is heated in air, it does not crystallize into dolomite but decomposes into Mg calcite, magnesium oxide, and CO2. Hence, this study heated ACMC in a closed system filled with CO2 gas (pCO2 >1.2 bar at 420 °C) and produced submicron-sized dolomite. Single-phase dolomite was obtained after dissolving impurities in the run products, such as northupite [Na3Mg(CO3)2Cl] and eitelite [Na2Mg(CO3)2], in water. Reference: ACS Omega. 2022 Nov 28;7(49):44670-44676. https://pubmed.ncbi.nlm.nih.gov/36530237/ |
| In vivo activity: | In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood samples for plasma were taken from all animals at different time points after administration. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption. Reference: Molecules. 2022 Sep 21;27(19):6188. https://pubmed.ncbi.nlm.nih.gov/36234733/ |
The following data is based on the product molecular weight 84.313 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Sugawara S, Fujiya W, Kagi H, Yamaguchi A, Hashizume K. Heat-Induced Dolomitization of Amorphous Calcium Magnesium Carbonate in a CO2-Filled Closed System. ACS Omega. 2022 Nov 28;7(49):44670-44676. doi: 10.1021/acsomega.2c03258. PMID: 36530237; PMCID: PMC9753508. 2. Yang L, Qu J, Gong D, Wang Z, Wang R, Wan L. Solventing out crystallization-basic magnesium carbonate percipitation for thorough phosphorus removal from ammonium tungstate solution. Front Chem. 2022 Aug 17;10:976376. doi: 10.3389/fchem.2022.976376. PMID: 36059872; PMCID: PMC9428244. 3. Zardán Gómez de la Torre T, Lindmark T, Cheung O, Bergström C, Strømme M. Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate-An In Vivo Evaluation. Molecules. 2022 Sep 21;27(19):6188. doi: 10.3390/molecules27196188. PMID: 36234733; PMCID: PMC9570901. |
| In vitro protocol: | 1. Sugawara S, Fujiya W, Kagi H, Yamaguchi A, Hashizume K. Heat-Induced Dolomitization of Amorphous Calcium Magnesium Carbonate in a CO2-Filled Closed System. ACS Omega. 2022 Nov 28;7(49):44670-44676. doi: 10.1021/acsomega.2c03258. PMID: 36530237; PMCID: PMC9753508. 2. Yang L, Qu J, Gong D, Wang Z, Wang R, Wan L. Solventing out crystallization-basic magnesium carbonate percipitation for thorough phosphorus removal from ammonium tungstate solution. Front Chem. 2022 Aug 17;10:976376. doi: 10.3389/fchem.2022.976376. PMID: 36059872; PMCID: PMC9428244. |
| In vivo protocol: | 1. Zardán Gómez de la Torre T, Lindmark T, Cheung O, Bergström C, Strømme M. Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate-An In Vivo Evaluation. Molecules. 2022 Sep 21;27(19):6188. doi: 10.3390/molecules27196188. PMID: 36234733; PMCID: PMC9570901. |
1: Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2018 Aug 22;8:CD006023. doi: 10.1002/14651858.CD006023.pub3. [Epub ahead of print] Review. PubMed PMID: 30132304.
2: Leukel S, Mondeshki M, Tremel W. Hydrogen Bonding in Amorphous Alkaline Earth Carbonates. Inorg Chem. 2018 Sep 4;57(17):11289-11298. doi: 10.1021/acs.inorgchem.8b02170. Epub 2018 Aug 20. PubMed PMID: 30124292.
3: Jensen ACS, Rodriguez I, Habraken WJEM, Fratzl P, Bertinetti L. Mobility of hydrous species in amorphous calcium/magnesium carbonates. Phys Chem Chem Phys. 2018 Jul 25;20(29):19682-19688. doi: 10.1039/c8cp01782d. PubMed PMID: 30014073.
4: Yang J, Alvebratt C, Lu X, Bergström CAS, Strømme M, Welch K. Amorphous magnesium carbonate nanoparticles with strong stabilizing capability for amorphous ibuprofen. Int J Pharm. 2018 Sep 5;548(1):515-521. doi: 10.1016/j.ijpharm.2018.07.021. Epub 2018 Jul 5. PubMed PMID: 29981897.
5: Ryb U, Eiler JM. Oxygen isotope composition of the Phanerozoic ocean and a possible solution to the dolomite problem. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6602-6607. doi: 10.1073/pnas.1719681115. Epub 2018 Jun 11. PubMed PMID: 29891710; PubMed Central PMCID: PMC6042145.
6: Alvebratt C, Cheung O, Strømme M, Bergström CAS. A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions. AAPS PharmSciTech. 2018 Jun 6. doi: 10.1208/s12249-018-1024-1. [Epub ahead of print] PubMed PMID: 29876792.
7: Emerson HP, Zengotita F, Richmann M, Katsenovich Y, Reed DT, Dittrich TM. Retention of neodymium by dolomite at variable ionic strength as probed by batch and column experiments. J Environ Radioact. 2018 Oct;190-191:89-96. doi: 10.1016/j.jenvrad.2018.05.007. PubMed PMID: 29775842.
8: Zhang X, Wang KL, Fu ZY, Chen HS, Zhang W, Shi ZH. [Hydrological characteristics of calcareous soil with contrasting architecture on dolomite slope of Northwest Guangxi]. Ying Yong Sheng Tai Xue Bao. 2017 Jul 18;28(7):2186-2196. doi: 10.13287/j.1001-9332.201707.028. Chinese. PubMed PMID: 29741049.
9: Khalfa A, Mellouk S, Marouf-Khelifa K, Khelifa A. Removal of catechol from water by modified dolomite: performance, spectroscopy, and mechanism. Water Sci Technol. 2018 Apr;77(7-8):1920-1930. doi: 10.2166/wst.2018.071. PubMed PMID: 29676749.
10: Bacon NT, Ryan GA, Wingo JE, Richardson MT, Pangallo T, Bishop PA. Effect of Magnesium Carbonate Use on Repeated Open-Handed and Pinch Grip Weight-Assisted Pull-Ups. Int J Exerc Sci. 2018 Jan 1;11(4):479-492. eCollection 2018. PubMed PMID: 29541333; PubMed Central PMCID: PMC5841679.
11: Li D, Gao X, Wang Y, Luo W. Diverse mechanisms drive fluoride enrichment in groundwater in two neighboring sites in northern China. Environ Pollut. 2018 Jun;237:430-441. doi: 10.1016/j.envpol.2018.02.072. Epub 2018 Mar 15. PubMed PMID: 29502006.
12: Schumacher SP, Schurgers LJ, Vervloet MG, Neradova A. Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study. Nephrology (Carlton). 2018 Feb 26. doi: 10.1111/nep.13245. [Epub ahead of print] PubMed PMID: 29479762.
13: Huang TH, Lai YJ, Hseu ZY. Efficacy of cheap amendments for stabilizing trace elements in contaminated paddy fields. Chemosphere. 2018 May;198:130-138. doi: 10.1016/j.chemosphere.2018.01.109. Epub 2018 Feb 6. PubMed PMID: 29421722.
14: Oo AZ, Sudo S, Akiyama H, Win KT, Shibata A, Yamamoto A, Sano T, Hirono Y. Effect of dolomite and biochar addition on N2O and CO2 emissions from acidic tea field soil. PLoS One. 2018 Feb 2;13(2):e0192235. doi: 10.1371/journal.pone.0192235. eCollection 2018. PubMed PMID: 29394272; PubMed Central PMCID: PMC5796709.
15: Gaury PK, Meena NK, Mahajan AK. Hydrochemistry and water quality of Rewalsar Lake of Lesser Himalaya, Himachal Pradesh, India. Environ Monit Assess. 2018 Jan 17;190(2):84. doi: 10.1007/s10661-017-6451-z. PubMed PMID: 29344735.
16: Shaaban M, Wu Y, Khalid MS, Peng QA, Xu X, Wu L, Younas A, Bashir S, Mo Y, Lin S, Zafar-Ul-Hye M, Abid M, Hu R. Reduction in soil N(2)O emissions by pH manipulation and enhanced nosZ gene transcription under different water regimes. Environ Pollut. 2018 Apr;235:625-631. doi: 10.1016/j.envpol.2017.12.066. Epub 2018 Jan 11. PubMed PMID: 29331895.
17: Rodrigues DCQ, Soares AP Junior, Costa EF Junior, Costa AOS. Dynamic Analysis of the Temperature and the Concentration Profiles of an Industrial Rotary Kiln Used in Clinker Production. An Acad Bras Cienc. 2017 Oct-Dec;89(4):3123-3136. doi: 10.1590/0001-3765201720160661. PubMed PMID: 29267803.
18: Ahmed SK, Ward JP, Liu Y. Numerical Modelling of Effects of Biphasic Layers of Corrosion Products to the Degradation of Magnesium Metal In Vitro. Materials (Basel). 2017 Dec 21;11(1). pii: E1. doi: 10.3390/ma11010001. PubMed PMID: 29267244; PubMed Central PMCID: PMC5793499.
19: Tice MM, Quezergue K, Pope MC. Microbialite Biosignature Analysis by Mesoscale X-ray Fluorescence (μXRF) Mapping. Astrobiology. 2017 Nov;17(11):1161-1172. doi: 10.1089/ast.2016.1494. PubMed PMID: 29135301.
20: Jiang L, Yao X, Yu H, Hou X, Zou Z, Shen F, Li C. Effect of permanent magnetic field on scale inhibition property of circulating water. Water Sci Technol. 2017 Oct;76(7-8):1981-1991. doi: 10.2166/wst.2017.357. PubMed PMID: 29068329.
