Valanimycin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341371

CAS#: 101961-60-8

Description: Valanimycin is a biochemical.

Chemical Structure

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Valanimycin
CAS# 101961-60-8
Instruction

Theoretical Analysis

MedKoo Cat#: 341371
Name: Valanimycin
CAS#: 101961-60-8
Chemical Formula: C7H12N2O3
Exact Mass: 172.08
Molecular Weight: 172.184
Elemental Analysis: C, 48.83; H, 7.03; N, 16.27; O, 27.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Valanimycin.

IUPAC/Chemical Name: 2-Propenoic acid, 2-((2-methylpropyl)-ONN-azoxy)-

InChi Key: DTXMRELKPKEPSO-HJWRWDBZSA-N

InChi Code: InChI=1S/C7H12N2O3/c1-5(2)4-9(12)8-6(3)7(10)11/h5H,3-4H2,1-2H3,(H,10,11)/b9-8-

SMILES Code: C=C(/N=[N+](CC(C)C)\[O-])C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 172.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mingyar E, Novakova R, Knirschova R, Feckova L, Bekeova C, Kormanec J. Unusual features of the large linear plasmid pSA3239 from Streptomyces aureofaciens CCM 3239. Gene. 2018 Feb 5;642:313-323. doi: 10.1016/j.gene.2017.11.046. Epub 2017 Nov 17. PubMed PMID: 29155332.

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3: Verdel-Aranda K, López-Cortina ST, Hodgson DA, Barona-Gómez F. Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity. Microb Biotechnol. 2015 Mar;8(2):239-52. doi: 10.1111/1751-7915.12175. Epub 2014 Oct 9. PubMed PMID: 25296650; PubMed Central PMCID: PMC4353338.

4: Garg RP, Parry RJ. Regulation of valanimycin biosynthesis in Streptomyces viridifaciens: characterization of VlmI as a Streptomyces antibiotic regulatory protein (SARP). Microbiology. 2010 Feb;156(Pt 2):472-83. doi: 10.1099/mic.0.033167-0. Epub 2009 Nov 5. PubMed PMID: 19892763; PubMed Central PMCID: PMC2890085.

5: Garg RP, Alemany LB, Moran S, Parry RJ. Identification, characterization, and bioconversion of a new intermediate in valanimycin biosynthesis. J Am Chem Soc. 2009 Jul 22;131(28):9608-9. doi: 10.1021/ja901243p. PubMed PMID: 19548668; PubMed Central PMCID: PMC2726733.

6: Garg RP, Qian XL, Alemany LB, Moran S, Parry RJ. Investigations of valanimycin biosynthesis: elucidation of the role of seryl-tRNA. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6543-7. doi: 10.1073/pnas.0708957105. Epub 2008 May 1. PubMed PMID: 18451033; PubMed Central PMCID: PMC2373340.

7: Garg RP, Gonzalez JM, Parry RJ. Biochemical characterization of VlmL, a Seryl-tRNA synthetase encoded by the valanimycin biosynthetic gene cluster. J Biol Chem. 2006 Sep 15;281(37):26785-91. Epub 2006 Jul 20. PubMed PMID: 16857674.

8: Tao T, Alemany LB, Parry RJ. Valanimycin biosynthesis: investigations of the mechanism of isobutylhydroxylamine incorporation. Org Lett. 2003 Apr 17;5(8):1213-5. PubMed PMID: 12688722.

9: Garg RP, Ma Y, Hoyt JC, Parry RJ. Molecular characterization and analysis of the biosynthetic gene cluster for the azoxy antibiotic valanimycin. Mol Microbiol. 2002 Oct;46(2):505-17. PubMed PMID: 12406225.

10: Skae P, Parry RJ. Determination of the stereochemistry of hydride transfer from NADPH to FAD catalyzed by VlmR, a flavin reductase from the valanimycin biosynthetic pathway. Org Lett. 2001 Apr 19;3(8):1117-9. PubMed PMID: 11348173.

11: Ma Y, Patel J, Parry RJ. A novel valanimycin-resistance determinant (vlmF) from Streptomyces viridifaciens MG456-hF10. Microbiology. 2000 Feb;146 ( Pt 2):345-52. PubMed PMID: 10708373.

12: Parry RJ, Li W. An NADPH:FAD oxidoreductase from the valanimycin producer, Streptomyces viridifaciens. Cloning, analysis, and overexpression. J Biol Chem. 1997 Sep 12;272(37):23303-11. PubMed PMID: 9287340.

13: Parry RJ, Li W. Purification and characterization of isobutylamine N-hydroxylase from the valanimycin producer Streptomyces viridifaciens MG456-hF10. Arch Biochem Biophys. 1997 Mar 1;339(1):47-54. PubMed PMID: 9056232.

14: Parry RJ, Li W, Cooper HN. Cloning, analysis, and overexpression of the gene encoding isobutylamine N-hydroxylase from the valanimycin producer, Streptomyces viridifaciens. J Bacteriol. 1997 Jan;179(2):409-16. PubMed PMID: 8990292; PubMed Central PMCID: PMC178710.

15: Yamato M, Umezawa H, Sakata N, Moriya Y, Hori M. Valanimycin acts on DNA in bacterial cells. J Antibiot (Tokyo). 1987 Apr;40(4):558-60. PubMed PMID: 3294774.

16: Yamato M, Takeuchi T, Umezawa H, Sakata N, Hayashi H, Hori M. Biosynthesis of valanimycin. J Antibiot (Tokyo). 1986 Sep;39(9):1263-9. PubMed PMID: 3781925.

17: Yamato M, Iinuma H, Naganawa H, Yamagishi Y, Hamada M, Masuda T, Umezawa H, Abe V, Hori M. Isolation and properties of valanimycin, a new azoxy antibiotic. J Antibiot (Tokyo). 1986 Feb;39(2):184-91. PubMed PMID: 3754251.