U 78753E

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581305

CAS#: 67450-78-6

Description: U 78753E is a biochemical.


Chemical Structure

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U 78753E
CAS# 67450-78-6

Theoretical Analysis

MedKoo Cat#: 581305
Name: U 78753E
CAS#: 67450-78-6
Chemical Formula: C16H22Cl2N2O
Exact Mass: 328.11
Molecular Weight: 329.270
Elemental Analysis: Chemical Formula: C16H22Cl2N2O Exact Mass: 328.1109 Molecular Weight: 329.2650 Elemental Analysis: C, 58.37; H, 6.74; Cl, 21.53; N, 8.51; O, 4.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: U 78753E; DCDPP; U-78753E; U-78753E;

IUPAC/Chemical Name: N-(2-(Dimethylamino)cyclopentyl)-N-(3,4-dichlorophenyl)propanamid

InChi Key: YCRFSKUCDBJWLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H22Cl2N2O/c1-4-16(21)20(11-8-9-12(17)13(18)10-11)15-7-5-6-14(15)19(2)3/h8-10,14-15H,4-7H2,1-3H3

SMILES Code: CCC(N(C1C(N(C)C)CCC1)C2=CC=C(Cl)C(Cl)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 329.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aaron CS, Stankowski LF Jr, Harbach PR, Valencia R, Mayo JK, Mirsalis J, Mazurek JH, Steinmetz KL, Wiser SK, Zimmer DM, et al. Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard. Mutat Res. 1989 Jun;223(2):111-20. PubMed PMID: 2500592.

2: Sethy VH, Day JS, Cooper MM. Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):673-82. PubMed PMID: 2851860.

3: Theis DL, Halstead GW, Capponi VJ, Roach BL, Robins RH. Quantitative determination of N-[trans-2-(dimethylamino)-cyclopentyl]-N-(3',4'-dichlorophenyl)propan amide, its 2H5-labeled analogue and their N-dealkylated metabolites in dog serum by capillary gas chromatography-mass spectrometry. J Chromatogr. 1986 Mar 7;375(2):299-311. PubMed PMID: 3700555.

4: Lakings DB, Stryd RP, Gilbertson TJ. Quantitative determination of N-(trans-2-dimethylaminocyclopentyl)-N-(3',4'-dichlorophenyl) propanamide and its N-demethyl metabolite in dog serum by gas chromatography. J Pharm Sci. 1984 Mar;73(3):317-20. PubMed PMID: 6716237.

5: Szmuszkovicz J, Von Voigtlander PF, Kane MP. A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds. J Med Chem. 1981 Oct;24(10):1230-6. PubMed PMID: 7328583.