Noremopamil

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MedKoo CAT#: 563912

CAS#: 86656-29-3 (racemic)

Description: Noremopamil is a calcium entry blocker, also being used as the precursor for radiolabelling emopamil.


Chemical Structure

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Noremopamil
CAS# 86656-29-3 (racemic)

Theoretical Analysis

MedKoo Cat#: 563912
Name: Noremopamil
CAS#: 86656-29-3 (racemic)
Chemical Formula: C22H28N2
Exact Mass: 320.23
Molecular Weight: 320.480
Elemental Analysis: C, 82.45; H, 8.81; N, 8.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 128194-57-0 (S-isomer)   186763-54-2 (R-isomer)   86656-29-3 (racemic)    

Synonym: Noremopamil; Desmethyl emopamil; Desmethyl-emopamil; Desmethylemopamil

IUPAC/Chemical Name: 2-Isopropyl-2-phenyl-5-[(2-phenylethyl)amino]pentanenitrile

InChi Key: SWJSQALWXRRRJA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H28N2/c1-19(2)22(18-23,21-12-7-4-8-13-21)15-9-16-24-17-14-20-10-5-3-6-11-20/h3-8,10-13,19,24H,9,14-17H2,1-2H3

SMILES Code: N#CC(C1=CC=CC=C1)(C(C)C)CCCNCCC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 320.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kimura T, Yamamoto N, Suzuki Y, Kawano K, Norimine Y, Ito K, Nagato S, Iimura Y, Yonaga M. Practical synthesis of chiral emopamil left hand as a bioactive motif. J Org Chem. 2002 Aug 23;67(17):6228-31. PubMed PMID: 12182667.

2: Weber J, Bielenberg GW, Krieglstein J. Effects of phenylalkylamine calcium entry blockers on postischemic energy metabolism in the isolated perfused rat brain: stereoselective action of emopamil. Pharmacology. 1988;37(1):38-49. PubMed PMID: 2458606.