ZYZ-803

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563902

CAS#: 2088043-51-8

Description: ZYZ-803 is a slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure.


Chemical Structure

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ZYZ-803
CAS# 2088043-51-8

Theoretical Analysis

MedKoo Cat#: 563902
Name: ZYZ-803
CAS#: 2088043-51-8
Chemical Formula: C20H23N3O6S
Exact Mass: 433.13
Molecular Weight: 433.480
Elemental Analysis: C, 55.42; H, 5.35; N, 9.69; O, 22.15; S, 7.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ZYZ-803; ZYZ 803; ZYZ803

IUPAC/Chemical Name: 3-(((N-(tert-Butoxycarbonyl)-S-(prop-2-yn-1-yl)cysteinyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

InChi Key: SXEWNJSLDYZELF-HNNXBMFYSA-N

InChi Code: InChI=1S/C20H23N3O6S/c1-5-11-30-13-15(21-19(25)28-20(2,3)4)18(24)27-12-16-17(22-29-23(16)26)14-9-7-6-8-10-14/h1,6-10,15H,11-13H2,2-4H3,(H,21,25)/t15-/m0/s1

SMILES Code: O=C(OCC1=[N+]([O-])ON=C1C2=CC=CC=C2)[C@H](CSCC#C)NC(OC(C)(C)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 433.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wu D, Hu Q, Xiong Y, Zhu D, Mao Y, Zhu YZ. Novel H(2)S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure. Redox Biol. 2018 May;15:243-252. doi: 10.1016/j.redox.2017.11.020. Epub 2017 Dec 14. PubMed PMID: 29288927; PubMed Central PMCID: PMC5975222.

2: Hu Q, Wu D, Ma F, Yang S, Tan B, Xin H, Gu X, Chen X, Chen S, Mao Y, Zhu YZ. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule. Antioxid Redox Signal. 2016 Sep 10;25(8):498-514. doi: 10.1089/ars.2015.6607. Epub 2016 Jun 29. PubMed PMID: 27174595.

3: Wu D, Hu Q, Ma F, Zhu YZ. Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway. Oxid Med Cell Longev. 2016;2016:7075682. doi: 10.1155/2016/7075682. Epub 2015 Nov 9. PubMed PMID: 26635911; PubMed Central PMCID: PMC4655279.