WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563895
Description: M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction.
MedKoo Cat#: 563895
Chemical Formula: C38H52FN5O6S
Exact Mass: 725.3622
Molecular Weight: 725.92
Elemental Analysis: C, 62.87; H, 7.22; F, 2.62; N, 9.65; O, 13.22; S, 4.42
This product is not in stock, which may be available by custom synthesis.
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Synonym: M-525; M525; M 525
IUPAC/Chemical Name: Methyl ((1S,2S)-2-((S)-(1-((1-(4-((1-((E)-4-(dimethylamino)but-2-enoyl)azetidin-3-yl)sulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)(3-fluorophenyl)(hydroxy)methyl)cyclopentyl)carbamate
InChi Key: FNGKXBSQGMOHOA-KZPMWZLFSA-N
InChi Code: InChI=1S/C38H52FN5O6S/c1-41(2)18-6-11-36(45)44-25-33(26-44)51(48,49)32-14-12-31(13-15-32)43-23-27(24-43)22-42-19-16-28(17-20-42)38(47,29-7-4-8-30(39)21-29)34-9-5-10-35(34)40-37(46)50-3/h4,6-8,11-15,21,27-28,33-35,47H,5,9-10,16-20,22-26H2,1-3H3,(H,40,46)/b11-6+/t34-,35-,38+/m0/s1
SMILES Code: O=C(OC)N[C@@H]1[C@@H]([C@](C2=CC=CC(F)=C2)(C3CCN(CC4CN(C5=CC=C(S(=O)(C6CN(C(/C=C/CN(C)C)=O)C6)=O)C=C5)C4)CC3)O)CCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 725.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. PubMed PMID: 29284071.