NAB-14
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563872

CAS#: 1237541-73-9

Description: NAB-14 is a selective negative allosteric modulator (NAM) for GluN2C/2D-containing NMDA receptors. NAB-14 inhibits synaptic transmission in hippocampal interneurons.


Chemical Structure

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NAB-14
CAS# 1237541-73-9

Theoretical Analysis

MedKoo Cat#: 563872
Name: NAB-14
CAS#: 1237541-73-9
Chemical Formula: C20H21N3O3
Exact Mass: 351.1583
Molecular Weight: 351.41
Elemental Analysis: C, 68.36; H, 6.02; N, 11.96; O, 13.66

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
10.0mg USD 370.0 2 Weeks
25.0mg USD 620.0 2 Weeks
50.0mg USD 1050.0 2 Weeks
100.0mg USD 1500.0 2 Weeks
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Synonym: NAB-14; NAB14; NAB 14

IUPAC/Chemical Name: 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate

InChi Key: WCGIKJOMEYPSIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)

SMILES Code: O=C(OC1=CC=C(C(NC2=CC=CC3=C2NC=C3)=O)C=C1)N(CC)CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 351.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. PubMed PMID: 29043770; PubMed Central PMCID: PMC5924706.

NAB-14

5.0mg / USD 230.0