WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563872
CAS#: 1237541-73-9
Description: NAB-14 is a selective negative allosteric modulator (NAM) for GluN2C/2D-containing NMDA receptors. NAB-14 inhibits synaptic transmission in hippocampal interneurons.
MedKoo Cat#: 563872
Name: NAB-14
CAS#: 1237541-73-9
Chemical Formula: C20H21N3O3
Exact Mass: 351.1583
Molecular Weight: 351.41
Elemental Analysis: C, 68.36; H, 6.02; N, 11.96; O, 13.66
Synonym: NAB-14; NAB14; NAB 14
IUPAC/Chemical Name: 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate
InChi Key: WCGIKJOMEYPSIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
SMILES Code: O=C(OC1=CC=C(C(NC2=CC=CC3=C2NC=C3)=O)C=C1)N(CC)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 351.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. PubMed PMID: 29043770; PubMed Central PMCID: PMC5924706.
