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NAB-14

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563872

CAS#: 1237541-73-9

Description: NAB-14 is a selective negative allosteric modulator (NAM) for GluN2C/2D-containing NMDA receptors. NAB-14 inhibits synaptic transmission in hippocampal interneurons.


Price and Availability

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NAB-14 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563872
Name: NAB-14
CAS#: 1237541-73-9
Chemical Formula: C20H21N3O3
Exact Mass: 351.1583
Molecular Weight: 351.41
Elemental Analysis: C, 68.36; H, 6.02; N, 11.96; O, 13.66


Synonym: NAB-14; NAB14; NAB 14

IUPAC/Chemical Name: 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate

InChi Key: WCGIKJOMEYPSIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)

SMILES Code: O=C(OC1=CC=C(C(NC2=CC=CC3=C2NC=C3)=O)C=C1)N(CC)CC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. PubMed PMID: 29043770; PubMed Central PMCID: PMC5924706.