WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563852
Description: P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
MedKoo Cat#: 563852
Chemical Formula: C15H17N5O3
Exact Mass: 315.1331
Molecular Weight: 315.33
Elemental Analysis: C, 57.13; H, 5.43; N, 22.21; O, 15.22
This product is not in stock, which may be available by custom synthesis.
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Synonym: P516-0475; P5160475; P516 0475; P-5160475; P 5160475
IUPAC/Chemical Name: N-(3-Methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide
InChi Key: IFMRJCJHUJEJJY-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H17N5O3/c1-9-4-5-11-10(8-9)17-15(22)13-12(18-19-20(11)13)14(21)16-6-3-7-23-2/h4-5,8H,3,6-7H2,1-2H3,(H,16,21)(H,17,22)
SMILES Code: O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 315.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Pérez Morales TG, Ratia K, Wang DS, Gogos A, Bloem L, Driver TG, Federle MJ. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. J Biol Chem. 2018 Jan 19;293(3):931-940. doi: 10.1074/jbc.M117.810994. Epub 2017 Dec 4. Erratum in: J Biol Chem. 2018 Mar 23;293(12 ):4580. Bloem, Laura [author added];. PubMed PMID: 29203527; PubMed Central PMCID: PMC5777264.