WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563839
CAS#: 362508-67-6 (free base)
Description: S101 is an inhibitor of proliferating T-cells, rescuing mice from superantigen-induced shock.
MedKoo Cat#: 563839
Name: S101
CAS#: 362508-67-6 (free base)
Chemical Formula: C24H23N3O3
Exact Mass: 401.1739
Molecular Weight: 401.47
Elemental Analysis: C, 71.80; H, 5.77; N, 10.47; O, 11.96
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 362508-67-6 (free base) 1251840-00-2 (sulfate)
Synonym: S101; S 101; S-101
IUPAC/Chemical Name: N-p-Tolyl-2-(3,4,5-trimethoxyphenyl)quinazolin-4-amine
InChi Key: SMRHGURAMRNJTP-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H23N3O3/c1-15-9-11-17(12-10-15)25-24-18-7-5-6-8-19(18)26-23(27-24)16-13-20(28-2)22(30-4)21(14-16)29-3/h5-14H,1-4H3,(H,25,26,27)
SMILES Code: COC1=C(OC)C(OC)=CC(C2=NC(NC3=CC=C(C)C=C3)=C4C=CC=CC4=N2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 401.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shir A, Klein S, Sagiv-Barfi I, Geiger T, Zigler M, Langut Y, Edinger N, Levitzki A. S101, an Inhibitor of Proliferating T Cells, Rescues Mice From Superantigen-Induced Shock. J Infect Dis. 2018 Jan 4;217(2):288-297. doi: 10.1093/infdis/jix576. PubMed PMID: 29149330.
