Oxamflatin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563828

CAS#: 151720-43-3

Description: Oxamflatin is a potent HDAC inhibitor, inhibiting the growth of mouse and human cancer cell lines.


Chemical Structure

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Oxamflatin
CAS# 151720-43-3

Theoretical Analysis

MedKoo Cat#: 563828
Name: Oxamflatin
CAS#: 151720-43-3
Chemical Formula: C17H14N2O4S
Exact Mass: 342.0674
Molecular Weight: 342.37
Elemental Analysis: C, 59.64; H, 4.12; N, 8.18; O, 18.69; S, 9.36

Price and Availability

Size Price Availability Quantity
1.0mg USD 245.0 2 Weeks
5.0mg USD 570.0 2 Weeks
10.0mg USD 950.0 2 Weeks
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Synonym:

IUPAC/Chemical Name: (E)-5-[3-(Benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide

InChi Key: QRPSQQUYPMFERG-LFYBBSHMSA-N

InChi Code: InChI=1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+

SMILES Code: O=C(NO)/C=C/C#CC1=CC=CC(NS(=O)(C2=CC=CC=C2)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Faghihloo E, Araei Y, Mohammadi M, Mirzaei H, Mohammadi HR, Mokhtari-Azad T. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23(11):396-399. doi: 10.1038/cgt.2016.52. Epub 2016 Oct 21. PubMed PMID: 27767089.

2: Wang YL, Liui HL, Fu RG, Wang ZW, Ren HT, Dai ZJ, Jing YY, Li Y. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16(3):232-42. PubMed PMID: 26917266.

3: Mao J, Zhao MT, Whitworth KM, Spate LD, Walters EM, O'Gorman C, Lee K, Samuel MS, Murphy CN, Wells K, Rivera RM, Prather RS. Oxamflatin treatment enhances cloned porcine embryo development and nuclear reprogramming. Cell Reprogram. 2015 Feb;17(1):28-40. doi: 10.1089/cell.2014.0075. Epub 2014 Dec 30. PubMed PMID: 25548976; PubMed Central PMCID: PMC4312790.

4: Hou L, Ma F, Yang J, Riaz H, Wang Y, Wu W, Xia X, Ma Z, Zhou Y, Zhang L, Ying W, Xu D, Zuo B, Ren Z, Xiong Y. Effects of histone deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2014 Aug;16(4):253-65. doi: 10.1089/cell.2013.0058. Epub 2014 Jun 24. PubMed PMID: 24960409; PubMed Central PMCID: PMC4116115.

5: Park SJ, Park HJ, Koo OJ, Choi WJ, Moon JH, Kwon DK, Kang JT, Kim S, Choi JY, Jang G, Lee BC. Oxamflatin improves developmental competence of porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2012 Oct;14(5):398-406. doi: 10.1089/cell.2012.0007. PubMed PMID: 23013534.

6: Su J, Wang Y, Li Y, Li R, Li Q, Wu Y, Quan F, Liu J, Guo Z, Zhang Y. Oxamflatin significantly improves nuclear reprogramming, blastocyst quality, and in vitro development of bovine SCNT embryos. PLoS One. 2011;6(8):e23805. doi: 10.1371/journal.pone.0023805. Epub 2011 Aug 30. PubMed PMID: 21912607; PubMed Central PMCID: PMC3166058.

7: Yin H, Zhang Y, Zhou X, Zhu H. Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. Mol Biol Rep. 2011 Nov;38(8):5071-8. doi: 10.1007/s11033-010-0653-6. Epub 2010 Dec 23. PubMed PMID: 21181272.

8: Dear AE, Liu HB, Mayes PA, Perlmutter P. Conformational analogues of Oxamflatin as histone deacetylase inhibitors. Org Biomol Chem. 2006 Oct 21;4(20):3778-84. Epub 2006 Aug 31. PubMed PMID: 17024284.

9: Dear AE, Medcalf RL. The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity. Biochim Biophys Acta. 2000 Jun 21;1492(1):15-22. PubMed PMID: 11004477.

10: Kim YB, Lee KH, Sugita K, Yoshida M, Horinouchi S. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18(15):2461-70. PubMed PMID: 10229197.

11: Sonoda H, Nishida K, Yoshioka T, Ohtani M, Sugita K. Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD. Oncogene. 1996 Jul 4;13(1):143-9. PubMed PMID: 8700540.