MBQ-167
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MedKoo CAT#: 407926

CAS#: 2097938-73-1

Description: MBQ-167 is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells. MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities. MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation.

Chemical Structure

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MBQ-167
CAS# 2097938-73-1
Instruction

Theoretical Analysis

MedKoo Cat#: 407926
Name: MBQ-167
CAS#: 2097938-73-1
Chemical Formula: C22H18N4
Exact Mass: 338.15
Molecular Weight: 338.414
Elemental Analysis: C, 78.08; H, 5.36; N, 16.56

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 Weeks
10mg USD 400 2 Weeks
25mg USD 750 2 Weeks
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Synonym: MBQ-167; MBQ167; MBQ 167;

IUPAC/Chemical Name: 9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole

InChi Key: LJCANTASZGYJLG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3

SMILES Code: CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rivera-Robles MJ, Medina-Velázquez J, Asencio-Torres GM, González-Crespo S,
Rymond BC, Rodríguez-Medina J, Dharmawardhane S. Targeting Cdc42 with the
anticancer compound MBQ-167 inhibits cell polarity and growth in the budding
yeast S. cerevisiae. Small GTPases. 2018 Jul 29:1-11. doi:
10.1080/21541248.2018.1495008. [Epub ahead of print] PubMed PMID: 29969362.


2: Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E,
Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ,
Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of a
Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017
May;16(5):805-818. doi: 10.1158/1535-7163.MCT-16-0442. PubMed PMID: 28450422;
PubMed Central PMCID: PMC5418092.