WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555320
Description: A-1293201 is a potent and selective NAMPT inhibitor.
MedKoo Cat#: 555320
Chemical Formula: C21H23N3O3
Exact Mass: 365.1739
Molecular Weight: 365.433
Elemental Analysis: C, 69.02; H, 6.34; N, 11.50; O, 13.13
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: A-1293201; A 1293201; A1293201;
IUPAC/Chemical Name: (S)-N-(4-(((tetrahydrofuran-3-yl)methyl)carbamoyl)phenyl)isoindoline-2-carboxamide
InChi Key: BLZJCPAXCWJANZ-HNNXBMFYSA-N
InChi Code: InChI=1S/C21H23N3O3/c25-20(22-11-15-9-10-27-14-15)16-5-7-19(8-6-16)23-21(26)24-12-17-3-1-2-4-18(17)13-24/h1-8,15H,9-14H2,(H,22,25)(H,23,26)/t15-/m0/s1
SMILES Code: O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 365.433 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Guo J, Lam LT, Longenecker KL, Bui MH, Idler KB, Glaser KB, Wilsbacher JL, Tse
C, Pappano WN, Huang TH. Identification of novel resistance mechanisms to NAMPT
inhibition via the de novo NAD(+) biosynthesis pathway and NAMPT mutation.
Biochem Biophys Res Commun. 2017 Sep 23;491(3):681-686. doi:
10.1016/j.bbrc.2017.07.143. Epub 2017 Jul 26. PubMed PMID: 28756225.