AMG-333
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555318

CAS#: 1416799-28-4

Description: AMG-333 is a potent and selective TRPM8 antagonist for the treatment of migraine. AMG-333 was well-tolerated in 28 day rat and dog preclinical safety studies and advanced to Phase 1 human clinical trials.


Chemical Structure

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AMG-333
CAS# 1416799-28-4

Theoretical Analysis

MedKoo Cat#: 555318
Name: AMG-333
CAS#: 1416799-28-4
Chemical Formula: C20H12F5N3O4
Exact Mass: 453.0748
Molecular Weight: 453.32
Elemental Analysis: C, 52.99; H, 2.67; F, 20.95; N, 9.27; O, 14.12

Price and Availability

Size Price Availability Quantity
25.0mg USD 350.0 2 Weeks
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1450.0 2 Weeks
500.0mg USD 2850.0 2 Weeks
1.0g USD 4250.0 2 Weeks
2.0g USD 6950.0 2 Weeks
Bulk inquiry

Synonym: AMG-333; AMG 333; AMG333;

IUPAC/Chemical Name: (S)-6-(((3-fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic acid

InChi Key: QEBYISWYMFIXOZ-INIZCTEOSA-N

InChi Code: InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)/t16-/m0/s1

SMILES Code: O=C(O)C1=CN=C(C(N[C@@H](C2=CC=C(OC(F)(F)F)C(F)=C2)C3=NC=CC=C3F)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 453.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Discovery of TRPM8 Antagonist (S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Daniel B. Horne, Kaustav Biswas, James Brown, Michael D. Bartberger, Jeffrey Clarine, Carl D. Davis, Vijay K. Gore, Scott Harried, Michelle Horner, Matthew R. Kaller, Sonya G. Lehto, Qingyian Liu, Vu V. Ma, Holger Monenschein, Thomas T. Nguyen, Chester C. Yuan, Beth D. Youngblood, Maosheng Zhang, Wenge Zhong, Jennifer R. Allen, Jian Jeffrey Chen, and Narender R. Gavva
Publication Date (Web): August 27, 2018 (Article) DOI: 10.1021/acs.jmedchem.8b00518

AMG-333

25.0mg / USD 350.0