RUN92619
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572674

CAS#: 1539292-61-9

Description: RUN92619, also known as 4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide is part of a new class of thiol-specific conjugation reagents consisting of a thiol-reactive 3-arylpropiolonitrile (APN) group. The APN group allows the targeted coupling of thiols in biomolecules, and results in stable thioether linkages without the risk of subsequent side reactions that can occur with maleimides. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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RUN92619
CAS# 1539292-61-9

Theoretical Analysis

MedKoo Cat#: 572674
Name: RUN92619
CAS#: 1539292-61-9
Chemical Formula: C13H13N3O
Exact Mass: 227.11
Molecular Weight: 227.270
Elemental Analysis: C, 68.70; H, 5.77; N, 18.49; O, 7.04

Price and Availability

Size Price Availability Quantity
25mg USD 320 2 Weeks
100mg USD 880 2 Weeks
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Synonym: 4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide; RUN 92619; RUN-92619; RUN92619

IUPAC/Chemical Name: 4-amino-N-(4-(2-cyanoethynyl)phenyl)butanamide

InChi Key: RLTVJTXRTMTNBC-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13N3O/c14-9-1-3-11-5-7-12(8-6-11)16-13(17)4-2-10-15/h5-8H,2,4,10,15H2,(H,16,17)

SMILES Code: O=C(NC1=CC=C(C#CC#N)C=C1)CCCN

Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: This product has good stability in aqueous media.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 227.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Badescu G, Bryant P, Swierkosz J, Khayrzad F, Pawlisz E, Farys M, Cong Y, Muroni M, Rumpf N, Brocchini S, Godwin A. A new reagent for stable thiol-specific conjugation. Bioconjug Chem. 2014 Mar 19;25(3):460-9. doi: 10.1021/bc400245v. Epub 2014 Feb 11. PubMed PMID: 24512057.