WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555315
CAS#: Unknown
Description: PSB-17183 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 = 115 nM).
MedKoo Cat#: 555315
Name: PSB-17183
CAS#: Unknown
Chemical Formula: C18H23NO5
Exact Mass: 333.1576
Molecular Weight: 333.384
Elemental Analysis: C, 64.85; H, 6.95; N, 4.20; O, 23.99
This product is not in stock, which may be available by custom synthesis.
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Synonym: PSB-17183; PSB 17183; PSB17183;
IUPAC/Chemical Name: 3-(2-Carboxyethyl)-6-(hexyloxy)-1H-indole-2-carboxylic Acid
InChi Key: LTXBACRGTNTVAA-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H23NO5/c1-2-3-4-5-10-24-12-6-7-13-14(8-9-16(20)21)17(18(22)23)19-15(13)11-12/h6-7,11,19H,2-5,8-10H2,1H3,(H,20,21)(H,22,23)
SMILES Code: O=C(C(N1)=C(CCC(O)=O)C2=C1C=C(OCCCCCC)C=C2)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 333.384 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M,
Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M,
Namasivayam V, Müller CE. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives:
Structural Requirements and Properties of Potent Agonists of the Orphan G
Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 5. doi:
10.1021/acs.jmedchem.7b01768. [Epub ahead of print] PubMed PMID: 30048589.
The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. GPR17 antagonists have potential for the
treatment of demyelinating diseases such as multiple sclerosis based on the observation that GPR17 knockout mice showed
increased myelination.
