WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555315

CAS#: Unknown

Description: PSB-17183 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 = 115 nM).

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 555315
Name: PSB-17183
CAS#: Unknown
Chemical Formula: C18H23NO5
Exact Mass: 333.16
Molecular Weight: 333.384
Elemental Analysis: C, 64.85; H, 6.95; N, 4.20; O, 23.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PSB-17183; PSB 17183; PSB17183;

IUPAC/Chemical Name: 3-(2-Carboxyethyl)-6-(hexyloxy)-1H-indole-2-carboxylic Acid


InChi Code: InChI=1S/C18H23NO5/c1-2-3-4-5-10-24-12-6-7-13-14(8-9-16(20)21)17(18(22)23)19-15(13)11-12/h6-7,11,19H,2-5,8-10H2,1H3,(H,20,21)(H,22,23)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: The orphan receptor GPR17 may be a novel drug target for inflammatory diseases. GPR17 antagonists have potential for the treatment of demyelinating diseases such as multiple sclerosis based on the observation that GPR17 knockout mice showed increased myelination.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 333.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Baqi Y, Pillaiyar T, Abdelrahman A, Kaufmann O, Alshaibani S, Rafehi M,
Ghasimi S, Akkari R, Ritter K, Simon K, Spinrath A, Kostenis E, Zhao Q, Köse M,
Namasivayam V, Müller CE. 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives:
Structural Requirements and Properties of Potent Agonists of the Orphan G
Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 5. doi:
10.1021/acs.jmedchem.7b01768. [Epub ahead of print] PubMed PMID: 30048589.