ICT2700

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563804

CAS#: NONE

Description: ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.


Chemical Structure

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ICT2700
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 563804
Name: ICT2700
CAS#: NONE
Chemical Formula: C21H18ClN3O2
Exact Mass: 379.1088
Molecular Weight: 379.84
Elemental Analysis: C, 66.40; H, 4.78; Cl, 9.33; N, 11.06; O, 8.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ICT2700; ICT 2700; ICT-2700; de-OH-CPI-MI; deOHCPIMI; de OH CPI MI

IUPAC/Chemical Name: (1-Chloromethyl-1,6-dihydro-2H-3,6-diaza-as-indacen-3-yl)-(6-methoxy-1H-indol-2-yl)-methanone

InChi Key: XRNCIYOOVQKJAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18ClN3O2/c1-27-14-3-2-12-8-18(24-17(12)9-14)21(26)25-11-13(10-22)20-15-6-7-23-16(15)4-5-19(20)25/h2-9,13,23-24H,10-11H2,1H3

SMILES Code: O=C(N1CC(CCl)C2=C1C=CC3=C2C=CN3)C(N4)=CC5=C4C=C(OC)C=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 379.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. PubMed PMID: 23033491.

2: Pors K, Loadman PM, Shnyder SD, Sutherland M, Sheldrake HM, Guino M, Kiakos K, Hartley JA, Searcey M, Patterson LH. Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chem Commun (Camb). 2011 Nov 28;47(44):12062-4. doi: 10.1039/c1cc15638a. Epub 2011 Oct 14. PubMed PMID: 22002321.