WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563804
Description: ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.
MedKoo Cat#: 563804
Chemical Formula: C21H18ClN3O2
Exact Mass: 379.1088
Molecular Weight: 379.84
Elemental Analysis: C, 66.40; H, 4.78; Cl, 9.33; N, 11.06; O, 8.42
This product is not in stock, which may be available by custom synthesis.
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Synonym: ICT2700; ICT 2700; ICT-2700; de-OH-CPI-MI; deOHCPIMI; de OH CPI MI
IUPAC/Chemical Name: (1-Chloromethyl-1,6-dihydro-2H-3,6-diaza-as-indacen-3-yl)-(6-methoxy-1H-indol-2-yl)-methanone
InChi Key: XRNCIYOOVQKJAV-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H18ClN3O2/c1-27-14-3-2-12-8-18(24-17(12)9-14)21(26)25-11-13(10-22)20-15-6-7-23-16(15)4-5-19(20)25/h2-9,13,23-24H,10-11H2,1H3
SMILES Code: O=C(N1CC(CCl)C2=C1C=CC3=C2C=CN3)C(N4)=CC5=C4C=C(OC)C=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 379.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. PubMed PMID: 23033491.
2: Pors K, Loadman PM, Shnyder SD, Sutherland M, Sheldrake HM, Guino M, Kiakos K, Hartley JA, Searcey M, Patterson LH. Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chem Commun (Camb). 2011 Nov 28;47(44):12062-4. doi: 10.1039/c1cc15638a. Epub 2011 Oct 14. PubMed PMID: 22002321.