ALZ-801
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MedKoo CAT#: 563784

CAS#: 1034190-08-3

Description: ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation for Alzheimer's disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability.


Chemical Structure

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ALZ-801
CAS# 1034190-08-3

Theoretical Analysis

MedKoo Cat#: 563784
Name: ALZ-801
CAS#: 1034190-08-3
Chemical Formula: C8H18N2O4S
Exact Mass: 238.0987
Molecular Weight: 238.3
Elemental Analysis: C, 40.32; H, 7.61; N, 11.76; O, 26.85; S, 13.45

Price and Availability

Size Price Availability Quantity
5.0mg USD 106.0 Same day
10.0mg USD 190.0 Same day
25.0mg USD 420.0 Same day
50.0mg USD 750.0 Same day
100.0mg USD 1375.0 Same day
200.0mg USD 1950.0 Same day
500.0mg USD 2950.0 Same day
1.0g USD 3850.0 2 Weeks
2.0g USD 6250.0 2 Weeks
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Related CAS #: 3687-18-1  

Synonym: ALZ-801; ALZ801; ALZ 801; BLU8499; BLU 8499; BLU-8499; NRM8499; NRM 8499; NRM-8499

IUPAC/Chemical Name: (S)-3-(2-Amino-3-methylbutanamido)propane-1-sulfonic acid

InChi Key: NRZRFNYKMSAZBI-ZETCQYMHSA-N

InChi Code: InChI=1S/C8H18N2O4S/c1-6(2)7(9)8(11)10-4-3-5-15(12,13)14/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13,14)/t7-/m0/s1

SMILES Code: O=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 238.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018 Aug 3. doi: 10.1007/s40263-018-0554-0. [Epub ahead of print] PubMed PMID: 30076539.

2: Abushakra S, Porsteinsson A, Scheltens P, Sadowsky C, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Wang P, Shen L, Tolar M. Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential. J Prev Alzheimers Dis. 2017;4(3):149-156. doi: 10.14283/jpad.2017.26. PubMed PMID: 29182706.

3: Hey JA, Yu JY, Versavel M, Abushakra S, Kocis P, Power A, Kaplan PL, Amedio J, Tolar M. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333. doi: 10.1007/s40262-017-0608-3. PubMed PMID: 29063518; PubMed Central PMCID: PMC5814546.

4: Kocis P, Tolar M, Yu J, Sinko W, Ray S, Blennow K, Fillit H, Hey JA. Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data. CNS Drugs. 2017 Jun;31(6):495-509. doi: 10.1007/s40263-017-0434-z. PubMed PMID: 28435985; PubMed Central PMCID: PMC5488121.

ALZ-801

5.0mg / USD 106.0