TOP1362
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555304

CAS#: 1630203-25-6

Description: TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 90 2 Weeks
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

TOP1362, purity > 97%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555304
Name: TOP1362
CAS#: 1630203-25-6
Chemical Formula: C43H51N7O8S
Exact Mass: 825.352
Molecular Weight: 825.982
Elemental Analysis: C, 62.53; H, 6.22; N, 11.87; O, 15.50; S, 3.88


Synonym: TOP1362; TOP-1362; TOP 1362;

IUPAC/Chemical Name: 3-((4-((4-(3-(5-(tert-butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(3-morpholinopropyl)benzamide

InChi Key: NIMKGKUGIJVPTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C43H51N7O8S/c1-43(2,3)29-24-36(40(56-5)37(25-29)49-59(6,53)54)48-42(52)47-35-12-13-38(34-11-8-7-10-33(34)35)58-31-14-16-44-39(27-31)46-30-22-28(23-32(26-30)55-4)41(51)45-15-9-17-50-18-20-57-21-19-50/h7-8,10-14,16,22-27,49H,9,15,17-21H2,1-6H3,(H,44,46)(H,45,51)(H2,47,48,52)

SMILES Code: CC(C)(C)C1=CC(NC(NC2=C(C=CC=C3)C3=C(OC4=CC=NC(NC5=CC(OC)=CC(C(NCCCN6CCOCC6)=O)=C5)=C4)C=C2)=O)=C(OC)C(NS(=O)(C)=O)=C1


Technical Data

Appearance:
Solid powder

Purity:
>97% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

TOP1362 is a potent inhibitor of kinases upregulated in DED and markedly attenuates proinflammatory cytokine release in vitro and in vivo, highlighting the therapeutic potential of NSKIs for treating ocular inflammation, such as that observed in DED.


References

1: Hagan S, Fyfe MCT, Ofori-Frimpong B, Oliver K, Foster MR, Sirohi S, Solanke Y, Doughty M, Rowley A, Taylor M, Webber S, Walshe CA. Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1443-1453. doi: 10.1167/iovs.17-23479. PubMed PMID: 29625466.