T2384

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MedKoo CAT#: 563746

CAS#: 315222-83-4

Description: T2384 is an antidiabetic agent with unique peroxisome proliferator-activated receptor gamma (PPARgamma) binding properties.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-07. Prices are subject to change without notice.

T2384 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563746
Name: T2384
CAS#: 315222-83-4
Chemical Formula: C20H10Cl3F3N2O2S3
Exact Mass: 567.8922
Molecular Weight: 569.83
Elemental Analysis: C, 42.16; H, 1.77; Cl, 18.66; F, 10.00; N, 4.92; O, 5.62; S, 16.88


Synonym: T2384; T-2384; T 2384

IUPAC/Chemical Name: 2-Chloro-N-[3-chloro-4-[(5-chloro-2-benzothiazolyl)thio]phenyl]-4-(trifluoromethyl)-benzenesulfonamide

InChi Key: BYUHFXVHEGWPSE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H10Cl3F3N2O2S3/c21-11-2-4-17-15(8-11)27-19(32-17)31-16-5-3-12(9-13(16)22)28-33(29,30)18-6-1-10(7-14(18)23)20(24,25)26/h1-9,28H

SMILES Code: O=S(C1=CC=C(C(F)(F)F)C=C1Cl)(NC2=CC=C(SC3=NC4=CC(Cl)=CC=C4S3)C(Cl)=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Hughes TS, Shang J, Brust R, de Vera IMS, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM, Kojetin DJ. Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluorome thyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy. J Med Chem. 2016 Nov 23;59(22):10335-10341. doi: 10.1021/acs.jmedchem.6b01340. Epub 2016 Nov 4. PubMed PMID: 27783520; PubMed Central PMCID: PMC5179221.

2: Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL. T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties. J Biol Chem. 2008 Apr 4;283(14):9168-76. doi: 10.1074/jbc.M800104200. Epub 2008 Feb 7. PubMed PMID: 18263587.