WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563746

CAS#: 315222-83-4

Description: T2384 is an antidiabetic agent with unique peroxisome proliferator-activated receptor gamma (PPARgamma) binding properties.

Chemical Structure

CAS# 315222-83-4

Theoretical Analysis

MedKoo Cat#: 563746
Name: T2384
CAS#: 315222-83-4
Chemical Formula: C20H10Cl3F3N2O2S3
Exact Mass: 567.8922
Molecular Weight: 569.83
Elemental Analysis: C, 42.16; H, 1.77; Cl, 18.66; F, 10.00; N, 4.92; O, 5.62; S, 16.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: T2384; T-2384; T 2384

IUPAC/Chemical Name: 2-Chloro-N-[3-chloro-4-[(5-chloro-2-benzothiazolyl)thio]phenyl]-4-(trifluoromethyl)-benzenesulfonamide


InChi Code: InChI=1S/C20H10Cl3F3N2O2S3/c21-11-2-4-17-15(8-11)27-19(32-17)31-16-5-3-12(9-13(16)22)28-33(29,30)18-6-1-10(7-14(18)23)20(24,25)26/h1-9,28H

SMILES Code: O=S(C1=CC=C(C(F)(F)F)C=C1Cl)(NC2=CC=C(SC3=NC4=CC(Cl)=CC=C4S3)C(Cl)=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 569.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hughes TS, Shang J, Brust R, de Vera IMS, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM, Kojetin DJ. Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluorome thyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy. J Med Chem. 2016 Nov 23;59(22):10335-10341. doi: 10.1021/acs.jmedchem.6b01340. Epub 2016 Nov 4. PubMed PMID: 27783520; PubMed Central PMCID: PMC5179221.

2: Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL. T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties. J Biol Chem. 2008 Apr 4;283(14):9168-76. doi: 10.1074/jbc.M800104200. Epub 2008 Feb 7. PubMed PMID: 18263587.