WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563737

CAS#: 26148-68-5

Description: AalphaC is a potential human carcinogen.

Chemical Structure

CAS# 26148-68-5

Theoretical Analysis

MedKoo Cat#: 563737
Name: AalphaC
CAS#: 26148-68-5
Chemical Formula: C11H9N3
Exact Mass: 183.0796
Molecular Weight: 183.21
Elemental Analysis: C, 72.11; H, 4.95; N, 22.94

Price and Availability

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5.0mg USD 260.0 2 Weeks
25.0mg USD 620.0 2 Weeks
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Synonym: AalphaC; Aalpha-C; Aalpha C; 2-Amino-alpha-carboline;

IUPAC/Chemical Name: 9H-Pyrido[2,3-b]indol-2-amine


InChi Code: InChI=1S/C11H9N3/c12-10-6-5-8-7-3-1-2-4-9(7)13-11(8)14-10/h1-6H,(H3,12,13,14)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 183.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Yuan ZX, Jha G, McGregor MA, King RS. Metabolites of the carcinogen 2-amino-alpha-carboline formed in male Sprague-Dawley rats in vivo and in rat hepatocyte and human HepG2 cell incubates. Chem Res Toxicol. 2007 Mar;20(3):497-503. Epub 2007 Feb 10. PubMed PMID: 17291013; PubMed Central PMCID: PMC2105743.

2: Smith CJ, Qian X, Zha Q, Moldoveanu SC. Analysis of alpha- and beta-carbolines in mainstream smoke of reference cigarettes by gas chromatography-mass spectrometry. J Chromatogr A. 2004 Aug 13;1046(1-2):211-6. PubMed PMID: 15387190.

3: Novak M, Nguyen TM. Unusual reactions of the model carcinogen N-acetoxy-N-acetyl-2-amino-alpha-carboline. J Org Chem. 2003 Dec 26;68(26):9875-81. PubMed PMID: 14682678.

4: Horie H, Zeisig M, Hirayama K, Midtvedt T, Möller L, Rafter J. Probiotic mixture decreases DNA adduct formation in colonic epithelium induced by the food mutagen 2-amino-9H-pyrido[2,3-b]indole in a human-flora associated mouse model. Eur J Cancer Prev. 2003 Apr;12(2):101-7. PubMed PMID: 12671533.

5: Hirayama K, Baranczewski P, Akerlund JE, Midtvedt T, Möller L, Rafter J. Effects of human intestinal flora on mutagenicity of and DNA adduct formation from food and environmental mutagens. Carcinogenesis. 2000 Nov;21(11):2105-11. PubMed PMID: 11062175.

6: King RS, Teitel CH, Kadlubar FF. In vitro bioactivation of N-hydroxy-2-amino-alpha-carboline. Carcinogenesis. 2000 Jul;21(7):1347-54. PubMed PMID: 10874013.

7: Stolc S. Indole derivatives as neuroprotectants. Life Sci. 1999;65(18-19):1943-50. Review. PubMed PMID: 10576443.

8: King RS, Teitel CH, Shaddock JG, Casciano DA, Kadlubar FF. Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative. Cancer Lett. 1999 Sep 1;143(2):167-71. PubMed PMID: 10503898.

9: Raza H, King RS, Squires RB, Guengerich FP, Miller DW, Freeman JP, Lang NP, Kadlubar FF. Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. Drug Metab Dispos. 1996 Apr;24(4):395-400. PubMed PMID: 8801053.

10: Gross GA, Turesky RJ, Fay LB, Stillwell WG, Skipper PL, Tannenbaum SR. Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings. Carcinogenesis. 1993 Nov;14(11):2313-8. PubMed PMID: 8242861.

11: Manabe S, Wada O, Kanai Y. Simultaneous determination of amino-alpha-carbolines and amino-gamma-carbolines in cigarette smoke condensate by high-performance liquid chromatography. J Chromatogr. 1990 Jul 13;529(1):125-33. PubMed PMID: 2211925.

12: Kato R. Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates. Crit Rev Toxicol. 1986;16(4):307-48. Review. PubMed PMID: 3519087.

13: Tohda H, Tada M, Sugawara R, Oikawa A. Actions of amino-beta-carbolines on induction of sister-chromatid exchanges. Mutat Res. 1983 Feb;116(2):137-47. PubMed PMID: 6828050.

14: Tsuda M, Nagao M, Hirayama T, Sugimura T. Nitrite converts 2-amino-alpha-carboline, an indirect mutagen, into 2-hydroxy-alpha-carboline, a non-mutagen, and 2-hydroxy-3-nitroso-alpha-carboline, a direct mutagen. Mutat Res. 1981 Aug;83(1):61-8. PubMed PMID: 6268972.

15: Tohda H, Oikawa A, Kawachi T, Sugimura T. Induction of sister-chromatid exchanges by mutagens from amino acid and protein pyrolysates. Mutat Res. 1980 Jan;77(1):65-9. PubMed PMID: 7360158.


5.0mg / USD 260.0