Oxalamine Citrate
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MedKoo CAT#: 563732

CAS#: 1949-20-8

Description: Oxalamine Citrate is a cough suppressant.

Chemical Structure

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Oxalamine Citrate
CAS# 1949-20-8
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563732
Name: Oxalamine Citrate
CAS#: 1949-20-8
Chemical Formula: C20H27N3O8
Exact Mass: 437.18
Molecular Weight: 437.449
Elemental Analysis: C, 54.91; H, 6.22; N, 9.61; O, 29.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Oxalamine Citrate; Oxalamine Citrate salt;

IUPAC/Chemical Name: N,N-Diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine citrate

InChi Key: RBZIGQJSMCOHSS-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code: CCN(CC)CCC1=NC(C2=CC=CC=C2)=NO1.OC(C(O)=O)(CC(O)=O)CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Oxolamine citrate (SKF-9976 citrate) is a cough suppressant.
In vitro activity: TBD
In vivo activity: After oral administration of warfarin at a dose of 2 mg/kg to male rats with oxolamine at doses of 10 and 50 mg/kg, the AUC values of warfarin were significantly greater than the controls (254 and 330 versus 180 microg h/ml). However, the AUC values of warfarin were not affected by oxolamine in female rats. This could be due to inhibition of CYP2B1, 2C11 and 3A2 by oxolamine in male rats, since warfarin was metabolized via CYP1A1, 2B1, 2C6, 2C11 and 3A2 in rats and CYP2B1 is male dominant, and CYP2C11 and 3A2 are male specific. Reference: Biopharm Drug Dispos. 2007 Apr;28(3):125-33. https://pubmed.ncbi.nlm.nih.gov/17295362/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 93.5 213.74
Water 28.7 65.48

Preparing Stock Solutions

The following data is based on the product molecular weight 437.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Zhu X, Lee DY, Shin WG. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28(3):125-33. doi: 10.1002/bdd.538. PMID: 17295362. 2. Silvestrini B, Pozzatti C. Pharmacological properties of 3-phenyl-5beta diethylaminoethyl-1,2,4-oxadiazole. Br J Pharmacol Chemother. 1961 Jun;16(3):209-17. doi: 10.1111/j.1476-5381.1961.tb01080.x. PMID: 19108149; PMCID: PMC1482017.
In vitro protocol: TBD
In vivo protocol: 1. Zhu X, Lee DY, Shin WG. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28(3):125-33. doi: 10.1002/bdd.538. PMID: 17295362. 2. Silvestrini B, Pozzatti C. Pharmacological properties of 3-phenyl-5beta diethylaminoethyl-1,2,4-oxadiazole. Br J Pharmacol Chemother. 1961 Jun;16(3):209-17. doi: 10.1111/j.1476-5381.1961.tb01080.x. PMID: 19108149; PMCID: PMC1482017.

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