Istaroxime HCl
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MedKoo CAT#: 563726

CAS#: 374559-48-5 (HCl)

Description: Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarcoplasmic reticulum calcium release, and by accelerating the inactivation state of L-type calcium channels, which allow for calcium influx.


Chemical Structure

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Istaroxime HCl
CAS# 374559-48-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 563726
Name: Istaroxime HCl
CAS#: 374559-48-5 (HCl)
Chemical Formula: C21H33ClN2O3
Exact Mass:
Molecular Weight: 396.956
Elemental Analysis: C, 63.54; H, 8.38; Cl, 8.93; N, 7.06; O, 12.09

Price and Availability

Size Price Availability Quantity
5.0mg USD 450.0 2 weeks
10.0mg USD 850.0 2 weeks
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Related CAS #: 203737-93-3 (free base)   203738-46-9 (E-isomer)   1046809-08-8 (Z-isomer)   374559-48-5 (HCl)   203737-94-4 (oxalate)    

Synonym: Istaroxime HCl; PST2744; PST 2744; PST-2744; PST-2744 HCl; PST-2744 hydrochloride

IUPAC/Chemical Name: (3E,5S,8R,9S,10R,13S,14S)-3-(2-Aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione Hydrochloride

InChi Key: AXHJYJDJXNOGNI-ROJIRLEOSA-N

InChi Code: InChI=1S/C21H32N2O3.ClH/c1-20-7-5-13(23-26-10-9-22)11-17(20)18(24)12-14-15-3-4-19(25)21(15,2)8-6-16(14)20;/h14-17H,3-12,22H2,1-2H3;1H/b23-13+;/t14-,15-,16-,17+,20+,21-;/m0./s1

SMILES Code: O=C(C[C@@]1([H])[C@]2([H])CC3)[C@@]4([H])C/C(CC[C@]4(C)[C@@]1([H])CC[C@]2(C)C3=O)=N/OCCN.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 396.956 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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12: Ferrandi M, Barassi P, Tadini-Buoninsegni F, Bartolommei G, Molinari I, Tripodi MG, Reina C, Moncelli MR, Bianchi G, Ferrari P. Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition. Br J Pharmacol. 2013 Aug;169(8):1849-61. doi: 10.1111/bph.12278. PubMed PMID: 23763364; PubMed Central PMCID: PMC3753840.

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