Naronapride dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 593022

CAS#: 860169-57-9

Description: Naronapride dihydrochloride is used in the Treatment of Gastric Disorder.


Price and Availability

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Naronapride dihydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 593022
Name: Naronapride dihydrochloride
CAS#: 860169-57-9
Chemical Formula: C27H43Cl3N4O5
Exact Mass: 608.2299
Molecular Weight: 610.01
Elemental Analysis: C, 53.16; H, 7.11; Cl, 17.43; N, 9.18; O, 13.11


Synonym: Naronapride dihydrochloride

IUPAC/Chemical Name: Naronapride dihydrochloride

InChi Key: ZKVOMYDQQYOJKE-HTKGJVFSSA-N

InChi Code: InChI=1S/C27H41ClN4O5.2ClH/c1-35-23-15-21(29)20(28)14-19(23)27(34)30-22-9-13-31(17-25(22)36-2)10-5-3-4-6-26(33)37-24-16-32-11-7-18(24)8-12-32;;/h14-15,18,22,24-25H,3-13,16-17,29H2,1-2H3,(H,30,34);2*1H/t22-,24+,25+;;/m1../s1

SMILES Code: O=C(N[C@H]1[C@H](CN(CCCCCC(O[C@H]2CN3CC[C@@H]2CC3)=O)CC1)OC)c4cc(Cl)c(N)cc4OC.Cl.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Bowersox SS, Lightning LK, Rao S, Palme M, Ellis D, Coleman R, Davies AM, Kumaraswamy P, Druzgala P. Metabolism and pharmacokinetics of naronapride (ATI-7505), a serotonin 5-HT(4) receptor agonist for gastrointestinal motility disorders. Drug Metab Dispos. 2011 Jul;39(7):1170-80. doi: 10.1124/dmd.110.037564. Epub 2011 Mar 29. PubMed PMID: 21447732.

2: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jun;29(5):359-73. PubMed PMID: 17805439.