Sulfamic acid | CAS#5329-14-6 | cleaning agent

Sulfamic acid
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558625

CAS#: 5329-14-6

Description: Sulfamic acid is used as an acidic cleaning agent typically for metals and ceramics. It is frequently used for removing rust and limescale.

Chemical Structure

Sulfamic acid

CAS# 5329-14-6

Instruction

Theoretical Analysis

MedKoo Cat#: 558625
Name: Sulfamic acid
CAS#: 5329-14-6
Chemical Formula: H3NO3S
Exact Mass: 96.98
Molecular Weight: 97.090
Elemental Analysis: H, 3.11; N, 14.43; O, 49.44; S, 33.02

Price and Availability

Size	Price	Availability	Quantity
100g	USD 210
500g	USD 380
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Sulfamic acid; Kyselina sulfaminova; Amidosulfuric acid; Aminosulfonic acid; Aminosulfuric acid;

IUPAC/Chemical Name: Sulfamic acid

InChi Key: IIACRCGMVDHOTQ-UHFFFAOYSA-N

InChi Code: InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4)

SMILES Code: O=S(O)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 97.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pszona M, Haupa K, Bil A, Mierzwicki K, Szewczuk Z, Mielke Z. Clustering of sulfamic acid: ESI MS and theoretical study. J Mass Spectrom. 2015 Jan;50(1):127-35. doi: 10.1002/jms.3505. PubMed PMID: 25601684.

2: Kamal A, Babu KS, Vishnu Vardhan MV, Hussaini SM, Mahesh R, Shaik SP, Alarifi A. Sulfamic acid promoted one-pot three-component synthesis and cytotoxic evaluation of spirooxindoles. Bioorg Med Chem Lett. 2015;25(10):2199-202. doi: 10.1016/j.bmcl.2015.03.054. Epub 2015 Mar 26. PubMed PMID: 25870131.

3: Spillane W, Malaubier JB. Sulfamic acid and its N- and O-substituted derivatives. Chem Rev. 2014 Feb 26;114(4):2507-86. doi: 10.1021/cr400230c. Epub 2013 Dec 17. PubMed PMID: 24341435.

4: Guo Y, Sato W, Shoyama K, Nakamura E. Sulfamic Acid-Catalyzed Lead Perovskite Formation for Solar Cell Fabrication on Glass or Plastic Substrates. J Am Chem Soc. 2016 Apr 27;138(16):5410-6. doi: 10.1021/jacs.6b02130. Epub 2016 Apr 15. PubMed PMID: 27054265.

5: Gucchait A, Jana M, Jana K, Misra AK. Preparation of glycosyl thiourea derivatives from glycosyl azides using sulfamic acid and sodium iodide in one-pot. Carbohydr Res. 2016 Nov 3;434:107-112. doi: 10.1016/j.carres.2016.09.002. Epub 2016 Sep 7. PubMed PMID: 27639336.

6: Li Q, Li S, Wang K, Li X, Liu J, Liu B, Zou G, Zou B. Pressure-induced isosymmetric phase transition in sulfamic acid: a combined Raman and x-ray diffraction study. J Chem Phys. 2013 Jun 7;138(21):214505. doi: 10.1063/1.4807864. PubMed PMID: 23758386.

7: Dupont D, Renders E, Raiguel S, Binnemans K. New metal extractants and super-acidic ionic liquids derived from sulfamic acid. Chem Commun (Camb). 2016 May 19;52(43):7032-5. doi: 10.1039/c6cc02350a. PubMed PMID: 27160926.

8: Xie W, Yang D. Silica-bonded N-propyl sulfamic acid used as a heterogeneous catalyst for transesterification of soybean oil with methanol. Bioresour Technol. 2011 Oct;102(20):9818-22. doi: 10.1016/j.biortech.2011.08.001. Epub 2011 Aug 9. PubMed PMID: 21871795.

9: Lusty JR, Hughes MN, Kelly DP. Inhibitory effects of sulfamic acid on three thiosulfate-oxidizing chemolithotrophs. FEMS Microbiol Lett. 2006 Nov;264(1):70-3. PubMed PMID: 17020550.

10: Granger J, Sigman DM. Removal of nitrite with sulfamic acid for nitrate N and O isotope analysis with the denitrifier method. Rapid Commun Mass Spectrom. 2009 Dec;23(23):3753-62. doi: 10.1002/rcm.4307. PubMed PMID: 19908214.

11: Heravi MM, Ranjbar L, Derikvand F, Alimadadi B. Three-component one-pot synthesis of 4,6-diarylpyrimidin- 2(1H)-ones under solvent-free conditions in the presence of sulfamic acid as a green and reusable catalyst. Mol Divers. 2008 Aug-Nov;12(3-4):191-6. doi: 10.1007/s11030-008-9089-5. Epub 2008 Oct 1. PubMed PMID: 18830679.

12: Klopfenstein SR, Evdokimov AG, Colson AO, Fairweather NT, Neuman JJ, Maier MB, Gray JL, Gerwe GS, Stake GE, Howard BW, Farmer JA, Pokross ME, Downs TR, Kasibhatla B, Peters KG. 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. Epub 2006 Jan 4. PubMed PMID: 16386905.

13: Wang X, Xiong Y, Xie T, Sharma VK, Tu Y, Yang J, Tian S, He C. Separation and determination of degradation products of acid orange 7 by capillary electrophoresis/capacitively coupled contactless conductivity detector. Talanta. 2013 Jul 15;111:54-61. doi: 10.1016/j.talanta.2013.03.032. Epub 2013 Mar 22. PubMed PMID: 23622525.

14: Brodfuehrer JI, Wilke TJ, Powis G. Pharmacokinetics and metabolism of the antitumor agent sulfamic acid 1,7-heptanediyl ester (sulfamic acid diester) in the mouse and beagle dog. Cancer Chemother Pharmacol. 1988;22(2):120-5. PubMed PMID: 3409442.

15: Zeng H, Li H, Shao H. One-pot three-component Mannich-type reactions using sulfamic acid catalyst under ultrasound irradiation. Ultrason Sonochem. 2009 Aug;16(6):758-62. doi: 10.1016/j.ultsonch.2009.03.008. Epub 2009 Mar 27. PubMed PMID: 19394889.

16: Scozzafava A, Banciu MD, Popescu A, Supuran CT. Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives. J Enzyme Inhib. 2000;15(5):443-53. PubMed PMID: 11030084.

17: Heravi MM, Alinejhad H, Bakhtiari K, Oskooie HA. Sulfamic acid catalyzed solvent-free synthesis of 10-aryl-7,7-dimethyl-6,7,8,10-tetrahydro-9H-[1,3]-dioxolo [4,5- b]xanthen-9-ones and 12-aryl-9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones. Mol Divers. 2010 Nov;14(4):621-6. doi: 10.1007/s11030-009-9196-y. Epub 2009 Sep 30. PubMed PMID: 19789988.

18: Ilinov P, Kojtscheva N. [Sulfamic acid as a charring reagent in thin layer chromatography. II. An attempt to separate free bile acids and bile acid conjugates]. Z Med Lab Diagn. 1980;21(4):220-4. German. PubMed PMID: 7467684.

19: Schmitt CR, Cagle GW. Sulfamic acid cleaning solution for 4,4'-methylene-bisorthochloroaniline (MOCA). Am Ind Hyg Assoc J. 1975 Mar;36(3):181-6. PubMed PMID: 1146681.

20: Patil SB, Singh PR, Surpur MP, Samant SD. Ultrasound-promoted synthesis of 1-amidoalkyl-2-naphthols via a three-component condensation of 2-naphthol, ureas/amides, and aldehydes, catalyzed by sulfamic acid under ambient conditions. Ultrason Sonochem. 2007 Jul;14(5):515-8. Epub 2006 Dec 4. PubMed PMID: 17145194.

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