Nylidrin hydrochloride
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MedKoo CAT#: 592951

CAS#: 849-55-8

Description: Nylidrin hydrochloride is a beta-adrenergic agonist. Nylidrin hydrochloride is shown to be an effective inhibitor of IgE-mediated release of histamine from human basophils, and thus can be used as antiallergic agent. It is also one of the FDA approved drug as Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP).


Price and Availability

Size Price Shipping out time Quantity
100mg USD 300 2 Weeks
250mg USD 450 2 Weeks
500mg USD 725 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-03-28. Prices are subject to change without notice.

Nylidrin hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 592951
Name: Nylidrin hydrochloride
CAS#: 849-55-8
Chemical Formula: C19H26ClNO2
Exact Mass: 335.1652
Molecular Weight: 335.87
Elemental Analysis: C, 67.95; H, 7.80; Cl, 10.55; N, 4.17; O, 9.53


Synonym: Nylidrin hydrochloride; Arlidin; Arlidin Hydrochloride; Bufedon; Buphedrin; Buphenine Hydrochloride; Dilatal; Dilatol; Dilatol Hydrochloride; Dilatropon; Dilydrin;

IUPAC/Chemical Name: Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, hydrochloride

InChi Key: CLJHABUMMDMAFA-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25NO2.ClH/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17;/h3-7,10-15,19-22H,8-9H2,1-2H3;1H

SMILES Code: OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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3: Montijo-Barrios E, Cadena F, Ramírez-Mayans JA, Gutiérrez-Castrellón P. [Clinical trial on the effect of buphenine, aminophenazone and diphenylpyraline hydrochloride in treating the common cold in children of 6 to 24 months of age]. Rev Invest Clin. 2011 Jul-Aug;63(4):335-43. Spanish. PubMed PMID: 22364032.

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6: Höfner G, Wanner KT. [3H]ifenprodil binding to NMDA receptors in porcine hippocampal brain membranes. Eur J Pharmacol. 2000 Apr 14;394(2-3):211-9. PubMed PMID: 10771286.

7: Brambilla G, Fiori M, Curiel I, Serpe L, Gallo P. Alpha 1-acid glycoprotein affinity columns for the clean-up of adrenergic drugs. Analyst. 1998 Dec;123(12):2693-6. PubMed PMID: 10435325.

8: Tamiz AP, Whittemore ER, Zhou ZL, Huang JC, Drewe JA, Chen JC, Cai SX, Weber E, Woodward RM, Keana JF. Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. PubMed PMID: 9719603.

9: Whittemore ER, Ilyin VI, Konkoy CS, Woodward RM. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208. PubMed PMID: 9430414.

10: Pahk AJ, Williams K. Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes. Neurosci Lett. 1997 Mar 28;225(1):29-32. PubMed PMID: 9143010.

11: Salokorpi T, Eronen M, von Wendt L. Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin. Neuropediatrics. 1996 Aug;27(4):174-7. PubMed PMID: 8892364.

12: Kaiser HJ, Flammer J, Stümpfig D, Hendrickson P. Visaline in the treatment of age-related macular degeneration: a pilot study. Ophthalmologica. 1995;209(6):302-5. PubMed PMID: 8751336.

13: Eronen M, Pesonen E, Kurki T, Teramo K, Ylikorkala O, Hallman M. Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. J Pediatr. 1994 May;124(5 Pt 1):782-8. PubMed PMID: 8176569.

14: Mercer LD, Jarrott B, Beart PM. 125I-ifenprodil: synthesis and characterization of binding to a polyamine-sensitive site in cerebral cortical membranes. J Neurochem. 1993 Jul;61(1):120-6. PubMed PMID: 8515257.

15: Eronen M. The hemodynamic effects of antenatal indomethacin and a beta-sympathomimetic agent on the fetus and the newborn: a randomized study. Pediatr Res. 1993 Jun;33(6):615-9. PubMed PMID: 8378121.

16: Kurki T, Viinikka L, Ylikorkala O. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):150-4. PubMed PMID: 1733190.

17: Spindler E, Janier M, Bonnin JM, Carlotti A, Daniel F. [Generalized exanthematous pustulosis caused by buphenine: report of a case]. Ann Dermatol Venereol. 1992;119(4):273-5. French. PubMed PMID: 1388340.

18: Kurki T, Eronen M, Lumme R, Ylikorkala O. A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Obstet Gynecol. 1991 Dec;78(6):1093-7. PubMed PMID: 1945214.

19: Kurki T, Laatikainen T, Salminen-Lappalainen K, Ylikorkala O. Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin. Br J Obstet Gynaecol. 1991 Jul;98(7):685-91. PubMed PMID: 1883793.

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