Ganhuangenin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461849

CAS#: 92519-91-0

Description: Ganhuangenin is a flavonoid from the root of gansuhuangqin (Scutellaria rehderiana) that has antioxidative properties.

Chemical Structure

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Ganhuangenin
CAS# 92519-91-0
Instruction

Theoretical Analysis

MedKoo Cat#: 461849
Name: Ganhuangenin
CAS#: 92519-91-0
Chemical Formula: C17H14O8
Exact Mass: 346.07
Molecular Weight: 346.290
Elemental Analysis: C, 58.96; H, 4.08; O, 36.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ganhuangenin; Sb 1; Sb-1; Sb1;

IUPAC/Chemical Name: 2-(3,6-dihydroxy-2-methoxyphenyl)-5,7-dihydroxy-8-methoxy-4H-chromen-4-one

InChi Key: CPFJPTACQDZPLS-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14O8/c1-23-15-8(19)4-3-7(18)14(15)12-6-10(21)13-9(20)5-11(22)16(24-2)17(13)25-12/h3-6,18-20,22H,1-2H3

SMILES Code: O=C1C=C(C2=C(O)C=CC(O)=C2OC)OC3=C(OC)C(O)=CC(O)=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 346.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lim BO, Yu BP, Kim SC, Park DK. The antioxidative effect of ganhuangenin against lipid peroxidation. Phytother Res. 1999 Sep;13(6):479-83. PubMed PMID: 10479757.

2: Lim BO. Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymph node lymphocytes in Sprague-Dawley rats. Phytother Res. 2002 Mar;16(2):166-70. PubMed PMID: 11933121.

3: Liu YL, Song WZ, Ji QY, Bai YL. [The structure of ganhuangenin, a new flavonoid from the root of gansuhuangqin (Scutellaria rehderiana)]. Yao Xue Xue Bao. 1984 Nov;19(11):830-5. Chinese. PubMed PMID: 6544550.

4: Liu Z, Wu J, Huang D. New stilbenoids isolated from fungus-challenged black skin peanut seeds and their adipogenesis inhibitory activity in 3T3-L1 cells. J Agric Food Chem. 2013 May 1;61(17):4155-61. doi: 10.1021/jf400144s. Epub 2013 Apr 17. PubMed PMID: 23560846.

5: Tsai PJ, Huang WC, Hsieh MC, Sung PJ, Kuo YH, Wu WH. Flavones Isolated from Scutellariae radix Suppress Propionibacterium Acnes-Induced Cytokine Production In Vitro and In Vivo. Molecules. 2015 Dec 24;21(1):E15. doi: 10.3390/molecules21010015. PubMed PMID: 26712724.

6: Su YL, Huang Y, Chen ZY. [Isolation and elucidation of antioxidant constituents from acetone extract in root of Scutellaria rehderiana]. Zhongguo Zhong Yao Za Zhi. 2004 Sep;29(9):863-4. Chinese. PubMed PMID: 15575204.

7: BERINGER A. [The therapy of diabetes mellitus with SB 1]. Wien Med Wochenschr. 1960 Feb 13;110:109-11. German. PubMed PMID: 13799474.

8: REGAMEY RH. [Study on the absence of antibacterial properties in a new synthetic antidiabetic, 1-(3-aminobenzenesulfonyl)-3-n-butylurea or SB 1]. Schweiz Med Wochenschr. 1959 Nov 7;89:1183-6. French. PubMed PMID: 14436950.

9: Kimura Y, Okuda H, Taira Z, Shoji N, Takemoto T, Arichi S. Studies on Scutellariae radix. IX. New component inhibiting lipid peroxidation in rat liver. Planta Med. 1984 Aug;50(4):290-5. PubMed PMID: 6548821.

10: BICKEL G, KORALNIK O. [First clinical trials of a new synthetic antidiabetic SB 1 or 1-(3-aminobenzenesulfonyl)-3-n-butylurea]. Schweiz Med Wochenschr. 1959 Nov 7;89:1186-91. French. PubMed PMID: 13800475.

11: Lim BO, Choue RW, Lee HY, Seong NS, Kim JD. Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats. Biosci Biotechnol Biochem. 2003 May;67(5):1126-9. PubMed PMID: 12834292.