WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563695
CAS#: 120876-23-5
Description: Protirelin Acetate is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
MedKoo Cat#: 563695
Name: Protirelin Acetate
CAS#: 120876-23-5
Chemical Formula: C38H56N12O14
Exact Mass: 904.4039
Molecular Weight: 904.93
Elemental Analysis: C, 50.44; H, 6.24; N, 18.57; O, 24.75
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Protirelin Acetate; Thyrotropin-releasing hormone; TRF Acetate; TRH Acetate; TSH-RF Acetate;
IUPAC/Chemical Name: N-(1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide sesquiacetate
InChi Key: FCUSEANSBYKTPA-UHFFFAOYSA-N
InChi Code: InChI=1S/2C16H22N6O4.3C2H4O2/c2*17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10;3*1-2(3)4/h2*7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25);3*1H3,(H,3,4)
SMILES Code: CC(O)=O.CC(O)=O.CC(O)=O.O=C(C(NC(C1CCC(N1)=O)=O)CC2=CN=CN2)N3C(C(N)=O)CCC3.O=C(C(NC(C4CCC(N4)=O)=O)CC5=CN=CN5)N6C(C(N)=O)CCC6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 904.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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18: Luo LG, Wang S, Su E, Jackson IM. Evidence from studies with N-ethyl-maleimide and 12-O-tetradecanoylphorbol-13-acetate that AP-1 and CREB are involved in the glucocorticoid activation of TRH gene expression in hypothalamic cultures. Brain Res. 1999 Sep 11;841(1-2):189-92. PubMed PMID: 10547001.
19: Galas L, Lamacz M, Garnier M, Roubos EW, Tonon MC, Vaudry H. Involvement of protein kinase C and protein tyrosine kinase in thyrotropin-releasing hormone-induced stimulation of alpha-melanocyte-stimulating hormone secretion in frog melanotrope cells. Endocrinology. 1999 Jul;140(7):3264-72. PubMed PMID: 10385423.
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