Sameridine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461746

CAS#: 143257-97-0 (free base)

Description: Sameridine is an amide-type local anesthetic-analgesic agent with a hexyl side chain.

Chemical Structure

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Sameridine
CAS# 143257-97-0 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 461746
Name: Sameridine
CAS#: 143257-97-0 (free base)
Chemical Formula: C21H35N2O
Exact Mass: 331.27
Molecular Weight: 331.520
Elemental Analysis: C, 76.08; H, 10.64; N, 8.45; O, 4.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 136483-84-6 (HCl)   143257-97-0 (free base)  

Synonym: Sameridine;

IUPAC/Chemical Name: N-ethyl-1-hexyl-1-methyl-4-phenyl-1l4-piperidine-4-carboxamide

InChi Key: RDNUKICZCGEFHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H35N2O/c1-4-6-7-11-16-23(3)17-14-21(15-18-23,20(24)22-5-2)19-12-9-8-10-13-19/h8-10,12-13H,4-7,11,14-18H2,1-3H3,(H,22,24)

SMILES Code: O=C(NCC)C1(C2=CC=CC=C2)CC[N](C)(CCCCCC)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sohlenius-Sternbeck AK, Chelpin HV, Orzechowski A, Halldin MM. Metabolism of sameridine to monocarboxylated products by hepatocytes isolated from the male rat. Drug Metab Dispos. 2000 Jun;28(6):695-700. PubMed PMID: 10820143.

2: Osterlund A, Arlander E, Eriksson LI, Lindahl SG. The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5. PubMed PMID: 9895085.

3: Osterlund Modalen A, Arlander E, Eriksson LI, Lindahl SG. The effects on hypercarbic ventilatory response of sameridine compared to morphine and placebo. Anesth Analg. 2001 Feb;92(2):529-34. PubMed PMID: 11159263.

4: Westman L, Valentin A, Eriksson E, Ekblom A. Intrathecal administration of sameridine to patients subjected to arthroscopic knee joint surgery. Acta Anaesthesiol Scand. 1998 Jul;42(6):691-7. PubMed PMID: 9689276.

5: Norsten-Höög C, Neidenström P, Arvidsson T. Determination of sameridine in blood plasma by nitrogen-selective gas chromatography. J Chromatogr B Biomed Sci Appl. 2001 Aug 25;760(1):123-7. PubMed PMID: 11522054.

6: Mulroy MF, Greengrass R, Ganapathy S, Chan V, Heierson A. Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair. Anesth Analg. 1999 Apr;88(4):815-21. PubMed PMID: 10195530.

7: Modalen AO, Westman L, Arlander E, Eriksson LI, Lindahl SG. Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine. Anesth Analg. 2003 Feb;96(2):570-5, table of contents. PubMed PMID: 12538214.

8: Karlsten R, Gordh T, Kristensen JD, Ask AL, Svensson BA. Sameridine--intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow. Acta Anaesthesiol Scand. 1999 May;43(5):573-9. PubMed PMID: 10342008.

9: Eklund E, Norsten-Höög C, Arvidsson T. Determination of free concentration of sameridine in blood plasma by ultrafiltration and coupled-column liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):195-200. PubMed PMID: 9653962.

10: Hollmann MW, Durieux ME, Graf BM. Novel local anaesthetics and novel indications for local anaesthetics. Curr Opin Anaesthesiol. 2001 Dec;14(6):741-9. PubMed PMID: 17019174.

11: Welin-Berger K, Neelissen JA, Engblom J. Physicochemical interaction of local anesthetics with lipid model systems--correlation with in vitro permeation and in vivo efficacy. J Control Release. 2002 May 17;81(1-2):33-43. PubMed PMID: 11992676.