WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563686
Description: IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.
MedKoo Cat#: 563686
Chemical Formula: C19H15NOS2
Exact Mass: 337.0595
Molecular Weight: 337.45
Elemental Analysis: C, 67.63; H, 4.48; N, 4.15; O, 4.74; S, 19.00
Synonym: IMB-10; IMB 10; IMB10;
IUPAC/Chemical Name: 5-(3-Phenyl-allylidene)-2-thioxo-3-o-tolyl-thiazolidin-4-one
InChi Key: UYZLENPCNZVWQZ-DNZSEPECSA-N
InChi Code: InChI=1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13-
SMILES Code: O=C1N(C2=CC=CC=C2C)C(S/C1=C\C=C\C3=CC=CC=C3)=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 337.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Suojanen J, Salo T, Sorsa T, Koivunen E. AlphaMbeta2 integrin modulator exerts antitumor activity in vivo. Anticancer Res. 2007 Nov-Dec;27(6B):3775-81. PubMed PMID: 18225532.
2: Björklund M, Aitio O, Stefanidakis M, Suojanen J, Salo T, Sorsa T, Koivunen E. Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment. Biochemistry. 2006 Mar 7;45(9):2862-71. PubMed PMID: 16503641.