WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461742
Description: Samarcandin is a natural sesquiterpene-coumarin that is isolated from F. assa-foetida.
MedKoo Cat#: 461742
Chemical Formula: C24H32O5
Exact Mass: 400.225
Molecular Weight: 400.51
Elemental Analysis: C, 71.97; H, 8.05; O, 19.97
This product is not in stock, which may be available by custom synthesis.
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IUPAC/Chemical Name: 7-(((1S,2R,4aR,6R,8aS)-2,6-dihydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methoxy)-2H-chromen-2-one
InChi Key: WNANPKYNOALKIV-XARGLDOUSA-N
InChi Code: InChI=1S/C24H32O5/c1-22(2)18-9-12-24(4,27)19(23(18,3)11-10-20(22)25)14-28-16-7-5-15-6-8-21(26)29-17(15)13-16/h5-8,13,18-20,25,27H,9-12,14H2,1-4H3/t18-,19+,20+,23-,24+/m0/s1
SMILES Code: O=C1C=CC2=C(O1)C=C(OC[C@H]3[C@](C)(O)CC[C@@]4([H])C(C)(C)[C@H](O)CC[C@]34C)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 400.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ghoran SH, Atabaki V, Babaei E, Olfatkhah SR, Dusek M, Eigner V, Soltani A, Khalaji AD. Isolation, spectroscopic characterization, X-ray, theoretical studies as well as in vitro cytotoxicity of Samarcandin. Bioorg Chem. 2016 Jun;66:27-32. doi: 10.1016/j.bioorg.2016.03.005. Epub 2016 Mar 15. PubMed PMID: 26998943.
2: Asghari J, Atabaki V, Baher E, Mazaheritehrani M. Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region. Nat Prod Res. 2016;30(3):350-3. doi: 10.1080/14786419.2015.1050669. Epub 2015 Jul 2. PubMed PMID: 26134757.
3: Ghannadi A, Fattahian K, Shokoohinia Y, Behbahani M, Shahnoush A. Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1. Iran J Pharm Res. 2014 Spring;13(2):523-30. PubMed PMID: 25237347; PubMed Central PMCID: PMC4157027.
4: Kasaian J, Mosaffa F, Behravan J, Masullo M, Piacente S, Iranshahi M. Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins. Phytother Res. 2016 Jan;30(1):84-9. doi: 10.1002/ptr.5504. Epub 2015 Oct 27. PubMed PMID: 26503061.
5: Abd El-Razek MH, Ohta S, Ahmed AA, Hirata T. Sesquiterpene coumarins from the roots of Ferula assa-foetida. Phytochemistry. 2001 Dec;58(8):1289-95. PubMed PMID: 11738424.