Salvianolic acid D

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461737

CAS#: 142998-47-8

Description: Salvianolic acid D is a compound that has been identified as a potential antiplatelet activity component.

Chemical Structure

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Salvianolic acid D
CAS# 142998-47-8
Instruction

Theoretical Analysis

MedKoo Cat#: 461737
Name: Salvianolic acid D
CAS#: 142998-47-8
Chemical Formula: C20H18O10
Exact Mass: 418.09
Molecular Weight: 418.350
Elemental Analysis: C, 57.42; H, 4.34; O, 38.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Salvianolic acid D;

IUPAC/Chemical Name: (R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid

InChi Key: KFCMFABBVSIHTB-WUTVXBCWSA-N

InChi Code: InChI=1S/C20H18O10/c21-13-4-1-10(7-15(13)23)8-16(20(28)29)30-18(26)6-3-11-2-5-14(22)19(27)12(11)9-17(24)25/h1-7,16,21-23,27H,8-9H2,(H,24,25)(H,28,29)/b6-3+/t16-/m1/s1

SMILES Code: O=C(O)[C@H](OC(/C=C/C1=CC=C(O)C(O)=C1CC(O)=O)=O)CC2=CC=C(O)C(O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li H, Cheng Y, Dong H, Wang X, Li J, Gao Q. Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography. J Chromatogr A. 2016 Oct 14;1468:42-48. doi: 10.1016/j.chroma.2016.09.039. Epub 2016 Sep 20. PubMed PMID: 27670752.

2: Chen X, Guo Y, Hu Y, Yu B, Qi J. Quantitative analysis of highly similar salvianolic acids with 1H qNMR for quality control of traditional Chinese medicinal preparation Salvianolate Lyophilized Injection. J Pharm Biomed Anal. 2016 May 30;124:281-287. doi: 10.1016/j.jpba.2016.02.016. Epub 2016 Feb 15. PubMed PMID: 26970983.

3: Miao J, Sun W, Huang J, Liu X, Li S, Han X, Tong L, Sun G. Characterization of metabolites in rats after intravenous administration of salvianolic acid for injection by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Biomed Chromatogr. 2016 Sep;30(9):1487-97. doi: 10.1002/bmc.3710. Epub 2016 Mar 14. PubMed PMID: 26910272.

4: Song J, Zhang W, Sun J, Xu X, Zhang X, Zhang L, Feng Z, Du GH. Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats. Acta Pharm Sin B. 2015 May;5(3):246-53. doi: 10.1016/j.apsb.2015.03.015. Epub 2015 Apr 27. PubMed PMID: 26579453; PubMed Central PMCID: PMC4629266.

5: Chen Y, Zhang N, Ma J, Zhu Y, Wang M, Wang X, Zhang P. A Platelet/CMC coupled with offline UPLC-QTOF-MS/MS for screening antiplatelet activity components from aqueous extract of Danshen. J Pharm Biomed Anal. 2016 Jan 5;117:178-83. doi: 10.1016/j.jpba.2015.06.009. Epub 2015 Jun 11. PubMed PMID: 26355772.

6: Li M, Wang F, Huang Y, Du F, Zhong C, Olaleye OE, Jia W, Li Y, Xu F, Dong J, Li J, Lim JB, Zhao B, Jia L, Li L, Li C. Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats, and dogs. Drug Metab Dispos. 2015 May;43(5):679-90. doi: 10.1124/dmd.114.061473. Epub 2015 Feb 10. PubMed PMID: 25670806.

7: Pan J, Gong X, Qu H. Quantitative (1)H NMR method for hydrolytic kinetic investigation of salvianolic acid B. J Pharm Biomed Anal. 2013 Nov;85:28-32. doi: 10.1016/j.jpba.2013.06.020. Epub 2013 Jun 26. PubMed PMID: 23867115.