TAMRA-PEG4-NHS ester | CAS#2171068-83-8 | Fluorescent PEG Linker

TAMRA-PEG4-NHS ester
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572365

CAS#: 2171068-83-8

Description: TAMRA-PEG4-NHS ester is a TAMRA red fluorescent dye derivative containing an NHS ester group which can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Chemical Structure

TAMRA-PEG4-NHS ester

CAS# 2171068-83-8

Instruction

Theoretical Analysis

MedKoo Cat#: 572365
Name: TAMRA-PEG4-NHS ester
CAS#: 2171068-83-8
Chemical Formula: C40H46N4O12
Exact Mass: 774.31
Molecular Weight: 774.820
Elemental Analysis: C, 62.01; H, 5.98; N, 7.23; O, 24.78

Price and Availability

Size	Price	Availability	Quantity
10mg	USD -1
1mg	USD 400
5mg	USD 1150
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: TAMRA-PEG4-NHS ester

IUPAC/Chemical Name: 2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)-5-((15-((2,5-dioxopyrrolidin-1-yl)oxy)-15-oxo-3,6,9,12-tetraoxapentadecyl)carbamoyl)benzoate

InChi Key: PKALNTYPHULONG-UHFFFAOYSA-N

InChi Code: InChI=1S/C40H46N4O12/c1-42(2)27-6-9-30-33(24-27)55-34-25-28(43(3)4)7-10-31(34)38(30)29-8-5-26(23-32(29)40(49)50)39(48)41-14-16-52-18-20-54-22-21-53-19-17-51-15-13-37(47)56-44-35(45)11-12-36(44)46/h5-10,23-25H,11-22H2,1-4H3,(H-,41,48,49,50)

SMILES Code: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)C(C=C2C([O-])=O)=CC=C2C(C3=C(C=C(N(C)C)C=C3)O4)=C(C=C/5)C4=CC5=[N+](C)\C

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, DMF, DCM, Water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: Solubility: Water, DMSO, DMF, DCM Excitation maximum (nm): 553 Extinction coefficient and excitation maximum, Lmol-1cm-1: 80000 Emission maximum (nm): 575

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 774.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen X, Zhang X, Wang HY, Chen Z, Wu FG. Subcellular Fate of a Fluorescent Cholesterol-Poly(ethylene glycol) Conjugate: An Excellent Plasma Membrane Imaging Reagent. Langmuir. 2016 Oct 4;32(39):10126-10135. Epub 2016 Sep 21. PubMed PMID: 27597442.

2: Chen G, Wang L, Cordie T, Vokoun C, Eliceiri KW, Gong S. Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging. Biomaterials. 2015 Apr;47:41-50. doi: 10.1016/j.biomaterials.2015.01.006. Epub 2015 Feb 4. PubMed PMID: 25682159; PubMed Central PMCID: PMC4329508.

3: Ruan S, Qian J, Shen S, Chen J, Zhu J, Jiang X, He Q, Yang W, Gao H. Fluorescent carbonaceous nanodots for noninvasive glioma imaging after angiopep-2 decoration. Bioconjug Chem. 2014 Dec 17;25(12):2252-9. doi: 10.1021/bc500474p. Epub 2014 Nov 11. PubMed PMID: 25387274.

4: Ruan S, Wan J, Fu Y, Han K, Li X, Chen J, Zhang Q, Shen S, He Q, Gao H. PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem. 2014 Jun 18;25(6):1061-8. doi: 10.1021/bc5001627. Epub 2014 May 22. PubMed PMID: 24852402.

5: Paira TK, Saha A, Banerjee S, Das T, Das P, Jana NR, Mandal TK. Fluorescent amphiphilic PEG-peptide-PEG triblock conjugate micelles for cell imaging. Macromol Biosci. 2014 Jul;14(7):929-35. doi: 10.1002/mabi.201400083. Epub 2014 Mar 31. PubMed PMID: 24687698.

6: Okuda T, Kobayashi Y, Yanamoto S, Okamoto H. PEG conjugation of a near-infrared fluorescent probe for noninvasive dual imaging of lung deposition and gene expression by pulmonary gene delivery. J Drug Target. 2012 Nov;20(9):801-12. doi: 10.3109/1061186X.2012.722639. Epub 2012 Sep 26. PubMed PMID: 23009266.

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