WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461721

CAS#: 2277-92-1

Description: Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats.

Chemical Structure

CAS# 2277-92-1

Theoretical Analysis

MedKoo Cat#: 461721
Name: Oxyclozanide
CAS#: 2277-92-1
Chemical Formula: C13H6Cl5NO3
Exact Mass: 398.879
Molecular Weight: 401.44
Elemental Analysis: C, 38.90; H, 1.51; Cl, 44.15; N, 3.49; O, 11.96

Price and Availability

Size Price Availability Quantity
100.0mg USD 260.0 2 Weeks
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Synonym: Oxyclozanide; Diplin; ICI 46683; ICI-46683; ICI46683; Oxiclozanida; Zanilox;

IUPAC/Chemical Name: 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide


InChi Code: InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)

SMILES Code: OC1=C(Cl)C=C(Cl)C(Cl)=C1C(NC2=CC(Cl)=CC(Cl)=C2O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 401.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gokbulut C, Yalinkilinc HS, Aksit D, Veneziano V. Comparative pharmacokinetics of levamisole-oxyclozanide combination in sheep and goats following per os administration. Can J Vet Res. 2014 Oct;78(4):316-20. PubMed PMID: 25356001; PubMed Central PMCID: PMC4170771.

2: Sanabria R, Moreno L, Alvarez L, Lanusse C, Romero J. Efficacy of oxyclozanide against adult Paramphistomum leydeni in naturally infected sheep. Vet Parasitol. 2014 Dec 15;206(3-4):277-81. doi: 10.1016/j.vetpar.2014.09.022. Epub 2014 Oct 7. PubMed PMID: 25458118.

3: Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E. Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus. PLoS One. 2015 Apr 21;10(4):e0124595. doi: 10.1371/journal.pone.0124595. eCollection 2015. PubMed PMID: 25897961; PubMed Central PMCID: PMC4405337.

4: Kang YJ, Wakabayashi C, Kim KH. Antihelminthic potential of quinacrine and oxyclozanide against gill parasite Microcotyle sebastis in black rockfish Sebastes schlegeli. Dis Aquat Organ. 2016 May 26;119(3):259-63. doi: 10.3354/dao02997. PubMed PMID: 27225210.

5: Whelan M, Chirollo C, Furey A, Cortesi ML, Anastasio A, Danaher M. Investigation of the persistence of levamisole and oxyclozanide in milk and fate in cheese. J Agric Food Chem. 2010 Dec 8;58(23):12204-9. doi: 10.1021/jf102725b. Epub 2010 Nov 8. PubMed PMID: 21058728.

6: Sakamoto M, Takeba K, Sasamoto T, Kusano T, Hayashi H, Kanai S, Kanda M, Nagayama T. Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry. J AOAC Int. 2010 Jul-Aug;93(4):1340-6. PubMed PMID: 20922970.

7: Oakley GA, Cockshott ID, Owen B. Acceptability of levamisole and oxyclozanide for the post parturient ewe and newborn lamb. Vet Rec. 1984 Apr 14;114(15):381-2. PubMed PMID: 6730244.

8: Paraud C, Gaudin C, Pors I, Chartier C. Efficacy of oxyclozanide against the rumen fluke Calicophoron daubneyi in experimentally infected goats. Vet J. 2009 May;180(2):265-7. doi: 10.1016/j.tvjl.2008.01.002. Epub 2008 Mar 7. PubMed PMID: 18314360.

9: Corba J, Pacenovský J, Krupicer I, Breza M, Popovic S, Reisz T. [Effectiveness of oxyclozanide in cattle naturally invaded by Liorchis scotiae trematoda]. Vet Med (Praha). 1976;21(8):461-5. Slovak. PubMed PMID: 828347.

10: Björk P, Källberg E, Wellmar U, Riva M, Olsson A, He Z, Törngren M, Liberg D, Ivars F, Leanderson T. Common interactions between S100A4 and S100A9 defined by a novel chemical probe. PLoS One. 2013 May 8;8(5):e63012. doi: 10.1371/journal.pone.0063012. Print 2013. PubMed PMID: 23667563; PubMed Central PMCID: PMC3648463.

11: Khan AR, Akhtar MJ, Mahmood R, Ahmed SM, Malook S, Iqbal M. LC assay method for oxfendazole and oxyclozanide in pharmaceutical preparation. J Pharm Biomed Anal. 2000 Feb;22(1):111-4. PubMed PMID: 10727129.

12: Georgiev B, Gruev A. [Effectiveness of levamisole and oxyclozanide in paramphistomiasis in sheep and cattle]. Vet Med Nauki. 1979;16(3):45-51. Bulgarian. PubMed PMID: 524749.

13: Edwards SR, Campbell AJ, Sheers M, Moore RJ, Montague PE. Studies of the effect of diamphenethide and oxyclozanide on the metabolism of Fasciola hepatica. Mol Biochem Parasitol. 1981 Apr;2(5-6):323-38. PubMed PMID: 7242570.

14: Arafa WM, Shokeir KM, Khateib AM. Comparing an in vivo egg reduction test and in vitro egg hatching assay for different anthelmintics against Fasciola species, in cattle. Vet Parasitol. 2015 Nov 30;214(1-2):152-8. doi: 10.1016/j.vetpar.2015.09.023. Epub 2015 Sep 30. PubMed PMID: 26455573.

15: Fujinuma K, Takeba K, Kamata K. [Concentration in plasma and excretion in milk of lactating cows after oral administration of tribromsalan, oxyclozanide and bromofenofos]. Shokuhin Eiseigaku Zasshi. 2006 Dec;47(6):249-53. Japanese. PubMed PMID: 17228788.

16: Coles GC, Stafford KA. Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica. Vet Rec. 2001 Jun 9;148(23):723-4. PubMed PMID: 11430684.

17: Dinç E, Kanbur M. Spectrophotometric multicomponent resolution of a veterinary formulation containing oxfendazole and oxyclozanide by multivariate calibration-prediction techniques. J Pharm Biomed Anal. 2002 May 15;28(3-4):779-88. PubMed PMID: 12008158.

18: Maffei Facino R, Carini M, Genchi C. Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide. Toxicol Lett. 1985 Jul;26(1):65-71. PubMed PMID: 3927525.

19: Romaniuk K, Lipiński Z. [Evaluation of the effectiveness of oxyclozanide (Zanil-Biowet and Zanil-ICI) and bromphenophos (Acedist IST) in the treatment of fascioliasis in cattle]. Wiad Parazytol. 1982;28(3-4):405-9. Polish. PubMed PMID: 6305038.

20: Yildirim A, Güneş V, Iça A, Sariözkan S, Düzlü O, Inci A, Albasan H. [The investigation of short term efficiency of oxfendazole + oxyclozanide paste and tablet formulations against gastrointestinal nematodes in sheep]. Turkiye Parazitol Derg. 2008;32(2):134-8. Turkish. PubMed PMID: 18645944.