WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563675
Description: G10 is a human-specific STING agonist, triggering IRF3/IFN-associated transcription in human fibroblasts.
MedKoo Cat#: 563675
Name: G10 STING agonist
Chemical Formula: C21H16ClFN2O3S
Exact Mass: 430.0554
Molecular Weight: 430.87
Elemental Analysis: C, 58.54; H, 3.74; Cl, 8.23; F, 4.41; N, 6.50; O, 11.14; S, 7.44
Synonym: G10; G-10; G 10; STING agonist G10;
IUPAC/Chemical Name: 4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide
InChi Key: NAGKYJATVFXZKN-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)
SMILES Code: O=C(C1=CC=C(C(N2CC3=C(F)C=CC=C3Cl)=C1)SCC2=O)NCC4=CC=CO4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 430.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed PMID: 26646986; PubMed Central PMCID: PMC4672893.