WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461702
CAS#: 85411-35-4
Description: Saframycin R is an antitumor antibiotic. Unlike other members of the saframycin family, saframycin R contains a reduced quinone ring bearing a glycolic ester moiety.
MedKoo Cat#: 461702
Name: Saframycin R
CAS#: 85411-35-4
Chemical Formula: C31H34N4O10
Exact Mass: 622.2275
Molecular Weight: 622.63
Elemental Analysis: C, 59.80; H, 5.50; N, 9.00; O, 25.70
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Synonym: Saframycin R;
IUPAC/Chemical Name: (6R,7R,9R,14aS,15R)-7-cyano-4-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-9-((2-oxopropanamido)methyl)-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-1-yl 2-hydroxyacetate
InChi Key: GATZXGIUISULHU-LJTNYMJHSA-N
InChi Code: InChI=1S/C31H34N4O10/c1-12-25(39)15-8-18-24-23-16(26(40)13(2)29(44-6)30(23)45-21(38)11-36)7-17(34(24)4)19(9-32)35(18)20(10-33-31(42)14(3)37)22(15)27(41)28(12)43-5/h17-20,24,36,40H,7-8,10-11H2,1-6H3,(H,33,42)/t17-,18+,19+,20+,24+/m1/s1
SMILES Code: O=C(OC1=C(C(C[C@](N2C)([H])[C@@H]3C#N)=C(O)C(C)=C1OC)[C@]2([H])[C@@]4([H])N3[C@@H](CNC(C(C)=O)=O)C5=C(C(C(C)=C(OC)C5=O)=O)C4)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 622.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Lown JW, Hanstock CC, Joshua AV, Arai T, Takahashi K. Structure and conformation of saframycin R determined by high field 1H and 13C NMR and its interactions with DNA in solution. J Antibiot (Tokyo). 1983 Sep;36(9):1184-94. PubMed PMID: 6630077.
2: Asaoka T, Yazawa K, Mikami Y, Arai T, Takahashi K. A new saframycin, saframycin R. J Antibiot (Tokyo). 1982 Dec;35(12):1708-10. PubMed PMID: 7166536.
3: Fukushima K, Yazawa K, Arai T. High performance liquid chromatography of saframycins, heterocyclic quinone antitumor antibiotics. J Antibiot (Tokyo). 1986 Nov;39(11):1602-4. PubMed PMID: 3793629.
