Saframycin R

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461702

CAS#: 85411-35-4

Description: Saframycin R is an antitumor antibiotic. Unlike other members of the saframycin family, saframycin R contains a reduced quinone ring bearing a glycolic ester moiety.

Chemical Structure

Saframycin R
CAS# 85411-35-4

Theoretical Analysis

MedKoo Cat#: 461702
Name: Saframycin R
CAS#: 85411-35-4
Chemical Formula: C31H34N4O10
Exact Mass: 622.23
Molecular Weight: 622.630
Elemental Analysis: C, 59.80; H, 5.50; N, 9.00; O, 25.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Saframycin R;

IUPAC/Chemical Name: (6R,7R,9R,14aS,15R)-7-cyano-4-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-9-((2-oxopropanamido)methyl)-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-1-yl 2-hydroxyacetate


InChi Code: InChI=1S/C31H34N4O10/c1-12-25(39)15-8-18-24-23-16(26(40)13(2)29(44-6)30(23)45-21(38)11-36)7-17(34(24)4)19(9-32)35(18)20(10-33-31(42)14(3)37)22(15)27(41)28(12)43-5/h17-20,24,36,40H,7-8,10-11H2,1-6H3,(H,33,42)/t17-,18+,19+,20+,24+/m1/s1

SMILES Code: O=C(OC1=C(C(C[C@](N2C)([H])[C@@H]3C#N)=C(O)C(C)=C1OC)[C@]2([H])[C@@]4([H])N3[C@@H](CNC(C(C)=O)=O)C5=C(C(C(C)=C(OC)C5=O)=O)C4)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 622.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lown JW, Hanstock CC, Joshua AV, Arai T, Takahashi K. Structure and conformation of saframycin R determined by high field 1H and 13C NMR and its interactions with DNA in solution. J Antibiot (Tokyo). 1983 Sep;36(9):1184-94. PubMed PMID: 6630077.

2: Asaoka T, Yazawa K, Mikami Y, Arai T, Takahashi K. A new saframycin, saframycin R. J Antibiot (Tokyo). 1982 Dec;35(12):1708-10. PubMed PMID: 7166536.

3: Fukushima K, Yazawa K, Arai T. High performance liquid chromatography of saframycins, heterocyclic quinone antitumor antibiotics. J Antibiot (Tokyo). 1986 Nov;39(11):1602-4. PubMed PMID: 3793629.