WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461700
CAS#: 66082-30-2
Description: Saframycin D is a dimeric isoquinolinequinone antibiotic.
MedKoo Cat#: 461700
Name: Saframycin D
CAS#: 66082-30-2
Chemical Formula: C28H31N3O9
Exact Mass: 553.206
Molecular Weight: 553.56
Elemental Analysis: C, 60.75; H, 5.64; N, 7.59; O, 26.01
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Synonym: Saframycin D;
IUPAC/Chemical Name: N-(((6R,9R,14aS,15S)-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)-2-oxopropanamide
InChi Key: JRGSNFZUTBSLSG-ZFCANOHDSA-N
InChi Code: InChI=1S/C28H31N3O9/c1-10-21(33)13-7-14-20-18-19(22(34)11(2)27(40-6)25(18)37)23(35)16(30(20)4)9-31(14)15(8-29-28(38)12(3)32)17(13)24(36)26(10)39-5/h14-16,20,34,37H,7-9H2,1-6H3,(H,29,38)/t14-,15-,16+,20+/m0/s1
SMILES Code: CC(C(NC[C@H]1C2=C(C(C(C)=C(OC)C2=O)=O)C[C@@](N1C[C@@]3([H])N4C)([H])[C@]4([H])C5=C(O)C(OC)=C(C)C(O)=C5C3=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 553.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kubo A, Saito N, Kitahara Y, Takahashi K, Yazawa K, Arai T. Structure of saframycin D, a new dimeric isoquinolinequinone antibiotic. Chem Pharm Bull (Tokyo). 1987 Jan;35(1):440-2. PubMed PMID: 3594668.
2: Fu CY, Tang MC, Peng C, Li L, He YL, Liu W, Tang GL. Biosynthesis of 3-hydroxy-5-methyl-o-methyltyrosine in the saframycin/ safracin biosynthetic pathway. J Microbiol Biotechnol. 2009 May;19(5):439-46. PubMed PMID: 19494690.
