Ammifurin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592820

CAS#: 8015-48-3

Description: Ammifurin is a Furocoumarin mixture used in treatment of vitiligo.

Chemical Structure

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Ammifurin
CAS# 8015-48-3
Instruction

Theoretical Analysis

MedKoo Cat#: 592820
Name: Ammifurin
CAS#: 8015-48-3
Chemical Formula: C25H18O9
Exact Mass: 462.10
Molecular Weight: 462.410
Elemental Analysis: C, 64.94; H, 3.92; O, 31.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ammifurin

IUPAC/Chemical Name: 4,9-Dimethoxy-7H-furo(3,2-g)(1)benzopyran-7-one mixt. with 4-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one

InChi Key: GIQRBVVYHBZHIU-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10O5.C12H8O4/c1-15-10-7-3-4-9(14)18-12(7)13(16-2)11-8(10)5-6-17-11;1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h3-6H,1-2H3;2-6H,1H3

SMILES Code: COc(c(OC(C=C1)=O)c1c2OC)c3c2cco3.COc(c(C=CC(O4)=O)c4c5)c6c5occ6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 462.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: INIAKHINA AV. [EXPERIENCE IN THE USE OF AMMIFURIN AND BEROXAN IN THE TREATMENT OF ALOPECIA AREATA]. Vestn Dermatol Venerol. 1964 Jan;38:59-61. Russian. PubMed PMID: 14177921.

2: VINOKUROV IN. [NEW SOVIET DRUGS, AMMIFURIN AND BEROXAN, FOR THE TREATMENT OF ALOPECIA AREATA AND VITILIGO]. Vestn Dermatol Venerol. 1963 Oct;37:10-4. Russian. PubMed PMID: 14130948.

3: Karagezian LA, Rostomian RB, Bagdasarova ZhG. [Treatment of vitiligo with ammifurin, beroxan and ultraviolet rays]. Vestn Dermatol Venerol. 1978 Nov;(11):64-6. Russian. PubMed PMID: 735345.

4: Mordovtsev VN, Langner A, Timoshin GG, Wolska H, Kirsanova MM. [Local PUVA therapy of patients with psoriasis]. Vestn Dermatol Venerol. 1989;(1):69-71. Russian. PubMed PMID: 2718622.

5: Pisarenko MF, Kaukhova OIa, Shablinskaia EM, Karagioz GI, Lopukhova GM. [PUVA therapy in chronic dermatoses using a domestic photosensitizer]. Vestn Dermatol Venerol. 1983 Sep;(9):52-5. Russian. PubMed PMID: 6649871.

6: Hoffmann JS, Moustacchi E, Villani G, Sage E. In vitro DNA synthesis by DNA polymerase I and DNA polymerase alpha on single-stranded DNA containing either purine or pyrimidine monoadducts. Biochem Pharmacol. 1992 Sep 25;44(6):1123-9. PubMed PMID: 1417935.