Zolpidem

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599235

CAS#: 82626-48-0 (free base)

Description: Zolpidem is discontinued (DEA schedule IV controlled substance). It is a nonbenzodiazepine; benzodiazepine receptor agonist; and one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors.


Chemical Structure

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Zolpidem
CAS# 82626-48-0 (free base)

Theoretical Analysis

MedKoo Cat#: 599235
Name: Zolpidem
CAS#: 82626-48-0 (free base)
Chemical Formula: C19H21N3O
Exact Mass: 307.1685
Molecular Weight: 307.39
Elemental Analysis: C, 74.24; H, 6.89; N, 13.67; O, 5.20

Price and Availability

Size Price Availability Quantity
5.0mg USD 390.0 2 Weeks
100.0mg USD 200.0 2 Weeks
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Related CAS #: 99294-93-6 (tartrate)   82626-48-0 (free base)   103188-50-7 (tartrate)    

Synonym: Zolpidem; SL 800750; SL-800750; SL800750; Zolpidemum; Lorex; SL 80-0750; SL-80-0750; SL80-0750

IUPAC/Chemical Name: N,N-dimethyl-2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetamide

InChi Key: ZAFYATHCZYHLPB-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

SMILES Code: O=C(N(C)C)CC1=C(C2=CC=C(C)C=C2)N=C3C=CC(C)=CN31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 307.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: MacFarlane J, Morin CM, Montplaisir J. Hypnotics in insomnia: the experience of zolpidem. Clin Ther. 2014 Nov 1;36(11):1676-701. doi: 10.1016/j.clinthera.2014.09.017. Epub 2014 Nov 19. Review. PubMed PMID: 25455931.

2: Huang HC, Tsai CH, Muo CH, Lin KH, Lu MK, Sung FC, Kao CH. Risk of Parkinson's disease following zolpidem use: a retrospective, population-based cohort study. J Clin Psychiatry. 2015 Jan;76(1):e104-10. doi: 10.4088/JCP.13m08790. PubMed PMID: 25650675.

3: Paulke A, Wunder C, Toennes SW. Sleep self-intoxication and sleep driving as rare zolpidem-induced complex behaviour. Int J Legal Med. 2015 Jan;129(1):85-8. doi: 10.1007/s00414-014-0997-x. Epub 2014 Apr 27. PubMed PMID: 24770472.

4: Jembrek MJ, Vlainić J, Šuran J. Zolpidem withdrawal induced uncoupling of GABA(A) receptors in vitro associated with altered GABA(A) receptor subunit mRNA expression. Acta Neurobiol Exp (Wars). 2015;75(2):160-71. PubMed PMID: 26232993.

5: Liao KF, Lin CL, Lai SW, Chen WC. Zolpidem Use Associated With Increased Risk of Pyogenic Liver Abscess: A Case-Control Study in Taiwan. Medicine (Baltimore). 2015 Aug;94(32):e1302. doi: 10.1097/MD.0000000000001302. PubMed PMID: 26266369; PubMed Central PMCID: PMC4616684.

6: Ho YH, Chang YC, Huang WC, Chen HY, Lin CC, Sung FC. Association between zolpidem use and glaucoma risk: a Taiwanese population-based case-control study. J Epidemiol. 2015;25(1):15-9. doi: 10.2188/jea.JE20140051. Epub 2014 Aug 23. PubMed PMID: 25720944; PubMed Central PMCID: PMC4275433.

7: Mehrdad R, Sadeghniiat Haghighi K, Naseri Esfahani AH. Effect of Zolpidem on Sleep Quality of Professional Firefighters; a Double Blind, Randomized, Placebo-Controlled Crossover Clinical Trial. Acta Med Iran. 2015;53(9):573-8. PubMed PMID: 26553086.

8: Lai SW, Lin CL, Liao KF. Increased relative risk of acute pancreatitis in zolpidem users. Psychopharmacology (Berl). 2015 Jun;232(12):2043-8. doi: 10.1007/s00213-014-3833-6. Epub 2014 Dec 10. PubMed PMID: 25491930.

9: Stockmann C, Gottschlich MM, Healy D, Khoury JC, Mayes T, Sherwin CM, Spigarelli MG, Kagan RJ. Relationship between zolpidem concentrations and sleep parameters in pediatric burn patients. J Burn Care Res. 2015 Jan-Feb;36(1):137-44. doi: 10.1097/BCR.0000000000000164. PubMed PMID: 25185933; PubMed Central PMCID: PMC5609879.

10: Berdyyeva T, Otte S, Aluisio L, Ziv Y, Burns LD, Dugovic C, Yun S, Ghosh KK, Schnitzer MJ, Lovenberg T, Bonaventure P. Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope. PLoS One. 2014 Nov 5;9(11):e112068. doi: 10.1371/journal.pone.0112068. eCollection 2014. PubMed PMID: 25372144; PubMed Central PMCID: PMC4221229.

11: Huang CY, Chou FH, Huang YS, Yang CJ, Su YC, Juang SY, Chen PF, Chou P, Lee CA, Lee CC. The association between zolpidem and infection in patients with sleep disturbance. J Psychiatr Res. 2014 Jul;54:116-20. doi: 10.1016/j.jpsychires.2014.03.017. Epub 2014 Mar 27. PubMed PMID: 24721551.

12: Thonnard M, Gosseries O, Demertzi A, Lugo Z, Vanhaudenhuyse A, Bruno MA, Chatelle C, Thibaut A, Charland-Verville V, Habbal D, Schnakers C, Laureys S. Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study. Funct Neurol. 2013 Oct-Dec;28(4):259-64. doi: 10.11138/FNeur/2013.28.4.259. PubMed PMID: 24598393; PubMed Central PMCID: PMC3951253.

13: Victorri-Vigneau C, Gérardin M, Rousselet M, Guerlais M, Grall-Bronnec M, Jolliet P. An update on zolpidem abuse and dependence. J Addict Dis. 2014;33(1):15-23. doi: 10.1080/10550887.2014.882725. Review. PubMed PMID: 24467433.

14: Harnod T, Li YF, Lin CL, Chang SN, Sung FC, Kao CH. Higher-dose uses of zolpidem will increase the subsequent risk of developing benign brain tumors. J Neuropsychiatry Clin Neurosci. 2015;27(2):e107-11. doi: 10.1176/appi.neuropsych.14010006. Epub 2014 Dec 12. PubMed PMID: 25923854.

15: Javelot H, Michel B, Steiner R, Javelot T, Cottencin O. Zolpidem test and catatonia. J Clin Pharm Ther. 2015 Dec;40(6):699-701. doi: 10.1111/jcpt.12330. Epub 2015 Nov 7. PubMed PMID: 26547135.

16: Schwope DM, DePriest A, Black DL, Caplan YH, Cone EJ, Heltsley R. Determining zolpidem compliance: urinary metabolite detection and prevalence in chronic pain patients. J Anal Toxicol. 2014 Oct;38(8):513-8. doi: 10.1093/jat/bku068. PubMed PMID: 25217539.

17: Fitzgerald AC, Wright BT, Heldt SA. The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABA(A) receptors. Psychopharmacology (Berl). 2014 May;231(9):1865-96. doi: 10.1007/s00213-014-3457-x. Epub 2014 Feb 22. Review. PubMed PMID: 24563183.

18: Lu TH, Lee YY, Lee HC, Lin YM. Doctor Shopping Behavior for Zolpidem Among Insomnia Patients in Taiwan: A Nationwide Population-Based Study. Sleep. 2015 Jul 1;38(7):1039-44. doi: 10.5665/sleep.4806. PubMed PMID: 25761979; PubMed Central PMCID: PMC4481003.

19: Kolla BP, Lovely JK, Mansukhani MP, Morgenthaler TI. Zolpidem is independently associated with increased risk of inpatient falls. J Hosp Med. 2013 Jan;8(1):1-6. doi: 10.1002/jhm.1985. Epub 2012 Nov 19. PubMed PMID: 23165956.

20: Greenblatt DJ, Roth T. Zolpidem for insomnia. Expert Opin Pharmacother. 2012 Apr;13(6):879-93. doi: 10.1517/14656566.2012.667074. Epub 2012 Mar 19. Review. PubMed PMID: 22424586.