Nithiamide
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MedKoo CAT#: 592817

CAS#: 140-40-9

Description: Nithiamide is an Antibacterial drug.


Price and Availability

Size Price Shipping out time Quantity
250mg USD 340 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-23. Prices are subject to change without notice.

Nithiamide purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 592817
Name: Nithiamide
CAS#: 140-40-9
Chemical Formula: C5H5N3O3S
Exact Mass: 187.0052
Molecular Weight: 187.17
Elemental Analysis: C, 32.09; H, 2.69; N, 22.45; O, 25.64; S, 17.13


Synonym: Nithiamide; NSC 45914; NSC-45914; NSC45914

IUPAC/Chemical Name: 2-Acetamido-5-nitrothiazole

InChi Key: UJRRDDHEMZLWFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)

SMILES Code: O=[N+](C1=CN=C(NC(C)=O)S1)[O-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Layton HW, Simkins KL, Eggert RG. Efficacy of nithiamide in preventing and treating swine dysentery in experimentally inoculated pigs. Am J Vet Res. 1977 May;38(5):627-31. PubMed PMID: 879561.

2: O'Shea JJ, Laurence A, McInnes IB. Back to the future: oral targeted therapy for RA and other autoimmune diseases. Nat Rev Rheumatol. 2013 Mar;9(3):173-82. doi: 10.1038/nrrheum.2013.7. Epub 2013 Feb 19. Review. PubMed PMID: 23419429; PubMed Central PMCID: PMC4169143.

3: Goodhew EB, Secor WE. Drug library screening against metronidazole-sensitive and metronidazole-resistant Trichomonas vaginalis isolates. Sex Transm Infect. 2013 Sep;89(6):479-84. doi: 10.1136/sextrans-2013-051032. Epub 2013 Jun 22. PubMed PMID: 23794105.

4: Kopteva LN. [Search for contact spermatocidal agents]. Akush Ginekol (Mosk). 1992 Feb;(2):67-70. Russian. PubMed PMID: 1476235.

5: Raynaud JP, Brunault G, Patterson EB. A swine dysentery model for evaluation of drug prophylaxis: efficacy of various drugs in the control of swine dysentery. Am J Vet Res. 1981 Jan;42(1):51-3. PubMed PMID: 7224318.

6: Beliaeva OA. [The treatment of intra-abdominal abscess]. Klin Khir. 1998;(7):32-3. Russian. PubMed PMID: 9989085.

7: ISSHIKI T, MASHIKO Y, NINOMYA M. On the polarography of 2-acetamido-5-nitrothiazole. Pharm Bull. 1954 Sep;2(3):256-8. PubMed PMID: 13215049.

8: Tarasenko SV, Aleksashina IP, Agapov VS, Trukhina GM, Liapunov NA. [The use of nitatsid and gipozol'-N in the combined treatment of acute inflammatory diseases of the maxillofacial area]. Stomatologiia (Mosk). 2000;79(2):17-9. Russian. PubMed PMID: 10812984.

9: KURNATOWSKA A. [Essay with 2-acetylamino-5-nitrothiazole in the treatment of vaginal trichomoniasis]. Wiad Parazytol. 1958;4(5-6):557-9; English transl 559-60. Polish, Portuguese. PubMed PMID: 13604196.

10: CAVIER R, SAVEL J, RUCART G. [Pharmacological study of a trichomonacidal drug: 2-acetylamino-5-nitrothiazole]. Therapie. 1958;13(3):502-7. French. PubMed PMID: 13603384.

11: FEO LG, FETTER TR. Evaluation of tritheon (aminitrozole) in male trichomoniasis. J Urol. 1958 Jul;80(1):72-4. PubMed PMID: 13564590.

12: BARNES J, BOUTWOOD A, HAINES E, LEWINGTON W, LISTER E, HARAM BJ. Oral treatment of trichomonas vaginitis with aminitrozole. Br Med J. 1957 May 18;1(5028):1160-2. PubMed PMID: 13426568; PubMed Central PMCID: PMC1973492.

13: HORTON-SMITH C, LONG PL. The effect of 2-amino-5-nitrothiazole, 2-acetylamino-5-nitrothiazole and furazolidone on the growth in vitro of Histomonas meleagridis. Ann Trop Med Parasitol. 1957 Mar;51(1):117-20. PubMed PMID: 13425322.

14: WILLCOX RR. Novobiocin, spiramycin, and aminitrozole in the treatment of non-gonococcal urethritis. Br J Vener Dis. 1957 Sep;33(3):180-1. PubMed PMID: 13471970; PubMed Central PMCID: PMC1054155.

15: BERTOLI PE. [2-acetylamino-5-nitrothiazole therapy of trichomonas vaginitis]. Minerva Ginecol. 1957 Dec 31;9(24):1006-10. Italian. PubMed PMID: 13516698.

16: Kalinichenko NF, Osolodchenko TP, Liapunov NA, Starobinets ZG. [Antibacterial activity of some trichomonacidal agents]. Antibiot Khimioter. 1990 Nov;35(11):34-7. Russian. PubMed PMID: 2092637.

17: WILLCOX RR. Treatment of vaginal trichomoniasis with aminitrozole and trichomycin given orally. Gynaecologia. 1960;149(Suppl):122-7. PubMed PMID: 13844789.

18: Tsarev VN, Ushakov RV. [The immunomodulating therapy of odontogenic phlegmons with complexes of antibacterial preparations and water-soluble polymers for medical use]. Stomatologiia (Mosk). 1996;Spec No:88. Russian. PubMed PMID: 9281191.

19: DUNLOP EM, PHILIPP E, WATT JD. Oral treatment of trichomonal vaginitis with 2-acetylamino-5-nitrothiazole (tritheon). Br J Vener Dis. 1958 Mar;34(1):57. PubMed PMID: 13523204; PubMed Central PMCID: PMC1047166.

20: BRET J. [Treatment of trichomonas vaginitis with oral & local 2-acetylamino-5-nitrothiazole]. C R Soc Fr Gyncol. 1958 Apr;28(4):218-25. French. PubMed PMID: 13573806.