S 9977

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461663

CAS#: 138472-18-1

Description: S 9977 is a trimethylxanthine derivative and putative promnesic drug.


Chemical Structure

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S 9977
CAS# 138472-18-1

Theoretical Analysis

MedKoo Cat#: 461663
Name: S 9977
CAS#: 138472-18-1
Chemical Formula: C20H34ClN7O3
Exact Mass: 455.2412
Molecular Weight: 455.98
Elemental Analysis: C, 52.68; H, 7.52; Cl, 7.77; N, 21.50; O, 10.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S 9977; S-9977; S9977; S-9977-2; S9977-2; S9977-2;

IUPAC/Chemical Name: N,N-diethyl-4-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propyl)piperazine-1-carboxamide hydrochloride

InChi Key: GVHZRDKDUVIRNY-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H33N7O3.ClH/c1-6-26(7-2)20(30)27-13-11-25(12-14-27)10-8-9-15-21-17-16(22(15)3)18(28)24(5)19(29)23(17)4;/h6-14H2,1-5H3;1H

SMILES Code: O=C(N1CCN(CCCC(N2C)=NC(N(C)C(N3C)=O)=C2C3=O)CC1)N(CC)CC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 455.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Trudeau LE, Fossier P, Baux G, Tauc L. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. PubMed PMID: 1380883.

2: Fernández-Novoa L, Alvarez XA, Détolle-Sarbach S, Guez D, Zas R, Polo E, Cacabelos R. Effects of S-9977-2 on histamine levels in rats. Methods Find Exp Clin Pharmacol. 1996 Apr;18(3):197-203. PubMed PMID: 8738071.

3: Schroeder H, Dumont I, Boyet S, Mocaër E, Nehlig A. Effects of the acute administration of a new trimethylxanthine derivative, S 9977-2, on local cerebral blood flow and glucose utilization in the rat. Eur J Pharmacol. 1992 Sep 22;220(2-3):217-29. PubMed PMID: 1425993.

4: Boulanger CM, Hughes H, Bond RA, Rafla E, Vanhoutte PM. Effects of S9977 on adrenergic neurotransmission. Gen Pharmacol. 1993 Mar;24(2):429-34. PubMed PMID: 8387054.

5: Villalón CM, Bom AH, Den Boer MO, Heiligers JP, Saxena PR. Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacol Res. 1992 Feb-Mar;25(2):125-37. PubMed PMID: 1635891.