Nalmefene HCl

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MedKoo CAT#: 563669

CAS#: 58895-64-0 (HCl)

Description: Nalmefene HCl is an antagonist of the opioid receptors.

Chemical Structure

Nalmefene HCl
CAS# 58895-64-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 563669
Name: Nalmefene HCl
CAS#: 58895-64-0 (HCl)
Chemical Formula: C21H26ClNO3
Exact Mass: 375.1601
Molecular Weight: 375.89
Elemental Analysis: C, 67.10; H, 6.97; Cl, 9.43; N, 3.73; O, 12.77

Price and Availability

Size Price Availability Quantity
50.0mg USD 350.0 2 Weeks
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Related CAS #: 55096-26-9 (free base)   58895-64-0 (HCl)   1228646-70-5 (HCl dihydrate)   1228646-72-7 (HCl hydrate)  

Synonym: Nalmefene Hydrochloride; Nalmefene HCl;

IUPAC/Chemical Name: 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride


InChi Code: InChI=1S/C21H25NO3.ClH/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H/t16-,19-,20+,21-;/m1./s1

SMILES Code: OC(C1=C2[C@@]34[C@@H]5O1)=CC=C2C[C@@H](N(CC6CC6)CC4)[C@]3(O)CCC5=C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 375.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Seidi S, Yamini Y, Rezazadeh M, Esrafili A. Low-voltage electrically-enhanced microextraction as a novel technique for simultaneous extraction of acidic and basic drugs from biological fluids. J Chromatogr A. 2012 Jun 22;1243:6-13. doi: 10.1016/j.chroma.2012.04.050. Epub 2012 Apr 26. PubMed PMID: 22575744.

2: Mason BJ, Ritvo EC, Morgan RO, Salvato FR, Goldberg G, Welch B, Mantero-Atienza E. A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcohol Clin Exp Res. 1994 Oct;18(5):1162-7. PubMed PMID: 7847600.

3: Simpkins JW, Swager D, Millard WJ. Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist. Neuroendocrinology. 1991 Oct;54(4):384-90. PubMed PMID: 1661859.

4: Fudala PJ, Johnson RE, Heishman SJ, Cone EJ, Henningfield JE. A dose run-up and safety evaluation of nalmefene HCl in human volunteers. NIDA Res Monogr. 1989;95:451-2. PubMed PMID: 2641028.

5: Simpkins JW, Smulkowski M, Dixon R, Tuttle R. Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J Pharmacol Exp Ther. 1988 Jan;244(1):195-205. PubMed PMID: 3335997.

6: Dixon R, Gentile J, Hsu HB, Hsiao J, Howes J, Garg D, Weidler D. Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist. J Clin Pharmacol. 1987 Mar;27(3):233-9. PubMed PMID: 3680580.