Nalmefene HCl
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MedKoo CAT#: 563669

CAS#: 58895-64-0 (HCl)

Description: Nalmefene HCl is an antagonist of the opioid receptors.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 350 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-09. Prices are subject to change without notice.

Nalmefene HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563669
Name: Nalmefene HCl
CAS#: 58895-64-0 (HCl)
Chemical Formula: C21H26ClNO3
Exact Mass: 375.1601
Molecular Weight: 375.89
Elemental Analysis: C, 67.10; H, 6.97; Cl, 9.43; N, 3.73; O, 12.77


Related CAS #: 55096-26-9 (free base)   58895-64-0 (HCl)   1228646-70-5 (HCl dihydrate)   1228646-72-7 (HCl hydrate)  

Synonym: Nalmefene Hydrochloride; Nalmefene HCl;

IUPAC/Chemical Name: 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride

InChi Key: GYWMRGWFQPSQLK-WFYNUGCWSA-N

InChi Code: InChI=1S/C21H25NO3.ClH/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H/t16-,19-,20+,21-;/m1./s1

SMILES Code: OC(C1=C2[C@@]34[C@@H]5O1)=CC=C2C[C@@H](N(CC6CC6)CC4)[C@]3(O)CCC5=C.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Seidi S, Yamini Y, Rezazadeh M, Esrafili A. Low-voltage electrically-enhanced microextraction as a novel technique for simultaneous extraction of acidic and basic drugs from biological fluids. J Chromatogr A. 2012 Jun 22;1243:6-13. doi: 10.1016/j.chroma.2012.04.050. Epub 2012 Apr 26. PubMed PMID: 22575744.

2: Mason BJ, Ritvo EC, Morgan RO, Salvato FR, Goldberg G, Welch B, Mantero-Atienza E. A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcohol Clin Exp Res. 1994 Oct;18(5):1162-7. PubMed PMID: 7847600.

3: Simpkins JW, Swager D, Millard WJ. Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist. Neuroendocrinology. 1991 Oct;54(4):384-90. PubMed PMID: 1661859.

4: Fudala PJ, Johnson RE, Heishman SJ, Cone EJ, Henningfield JE. A dose run-up and safety evaluation of nalmefene HCl in human volunteers. NIDA Res Monogr. 1989;95:451-2. PubMed PMID: 2641028.

5: Simpkins JW, Smulkowski M, Dixon R, Tuttle R. Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J Pharmacol Exp Ther. 1988 Jan;244(1):195-205. PubMed PMID: 3335997.

6: Dixon R, Gentile J, Hsu HB, Hsiao J, Howes J, Garg D, Weidler D. Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist. J Clin Pharmacol. 1987 Mar;27(3):233-9. PubMed PMID: 3680580.