S 8308

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461660

CAS#: 119256-78-9

Description: S 8308 is a weak, but specific and competitive, non-peptide antagonist of AII exerting its inhibitory action at the receptor level.


Chemical Structure

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S 8308
CAS# 119256-78-9

Theoretical Analysis

MedKoo Cat#: 461660
Name: S 8308
CAS#: 119256-78-9
Chemical Formula: C16H17ClN3NaO4
Exact Mass: 373.0805
Molecular Weight: 373.76
Elemental Analysis: C, 51.42; H, 4.58; Cl, 9.48; N, 11.24; Na, 6.15; O, 17.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S 8308; S-8308; S8308;

IUPAC/Chemical Name: sodium 2-(2-butyl-4-chloro-1-(2-nitrobenzyl)-1H-imidazol-5-yl)acetate

InChi Key: IOLLRZYQFFZPKF-UHFFFAOYSA-M

InChi Code: InChI=1S/C16H18ClN3O4.Na/c1-2-3-8-14-18-16(17)13(9-15(21)22)19(14)10-11-6-4-5-7-12(11)20(23)24;/h4-7H,2-3,8-10H2,1H3,(H,21,22);/q;+1/p-1

SMILES Code: O=C([O-])CC1=C(Cl)N=C(CCCC)N1CC2=CC=CC=C2[N+]([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 373.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chiu AT, Duncia JV, McCall DE, Wong PC, Price WA Jr, Thoolen MJ, Carini DJ, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies. J Pharmacol Exp Ther. 1989 Sep;250(3):867-74. PubMed PMID: 2778716.

2: Chiu AT, Carini DJ, Johnson AL, McCall DE, Price WA, Thoolen MJ, Wong PC, Taber RI, Timmermans PB. Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308. Eur J Pharmacol. 1988 Nov 15;157(1):13-21. PubMed PMID: 3234494.